不同降压程度对全髋关节置换老年患者术后认知功能的影响  

EFFECTS OF DIFFERENT HYPOTENSION LEVELS ON COGNITIVE FUNCTION AFTER TOTAL HIP REPLACEMENT IN GERIATRIC PATIENS

作　　者：霍树平[1] 赵华宇[1] 王秀丽[1] 王秋筠[1] 

机构地区：[1]河北医科大学第三医院麻醉科,河北石家庄050051

出　　处：《河北医科大学学报》2012年第12期1415-1417,共3页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题计划(2009-0414)

摘　　要：目的探讨不同降压程度对控制性降压的老年患者术后认知功能的影响。方法选择期手术老年患者(≥65岁)60例,根据降压程度不同随机分为3组(每组20例),对照组(F_0组)和控制性降压组,控制性降压组患者采用不同降压程度控制性降压分为F_1组(基础值25%)和F_2组(基础值35%),控制性降压采用硝酸甘油降压维持1h;分别于术前1h,术后24、48、96h对各组患者应用简易智能状态检查法(mini-mental state examination,MMSE)评估术后认知功能。结果与术前1h和F_0组比较,F_2组在术后24h MMSE评分下降(P<0.05)。结论老年患者硝酸甘油控制性降压在基础值降低25%程度维持1 h时是安全可行的。Objective To investigate the effects of different hypotension levels on congnitive function in geriatric patients. Methods Sixty geriatric patients were randomly assigned to 3 groups （ n = 20 each） ：controlled hypotension F1 group, controlled hypotension F2 group and control group（ Group F0 ）. In F1 group mean arterial pressure （MAP） was decreased 25% and in F2 group MAP was decreased 35% by nitroglycerin（NTG） infusion in one hour. The mini -mental state examination（MMSE） was used to assess cognitive function l h before operation and 24,48,96h after surgery. Results MMES score was reduced at 24h after surgery compared to that at 1 h before operation in F2 group （P 〈 0.05 ）. MMES score was reduced in F2 group compared to that in F0 group at 24h after surgery （P 〈 0.05 ）. Conclusion It is safe and feasible that MAP is decreased 25% by NTG infusion for lh in geriatric patiens.

关 键 词：降压 控制性 认知 老年人 

分 类 号：R687.4[医药卫生—骨科学]