羟基磷灰石涂层的钛-75合金种植体的犬骨内种植实验  

Experimental study of hydroxyapatite coated Ti-75 alloy implant in dogs

作　　者：胡科军[1] 陈必胜[2] 陶长仲[2] 姜晓钟[2] 曾绍先 杨志雄[3] 

机构地区：[1]海军411医院颌面外科,上海200081 [2]第二军医大学长征医院口腔科,上海200003 [3]中国科学院上海硅酸盐研究所

出　　处：《第二军医大学学报》2000年第3期290-293,共4页Academic Journal of Second Military Medical University

摘　　要：目的 :观察评估羟基磷灰石 (HA)烧结涂层的钛 - 75 (Ti- 75 )合金种植体 (HATI)的生物学性能与生物力学特性。 方法 :应用穿皮质骨种植模型 ,以纯钛种植体 (PTI)作对照 ,在双侧犬股骨内种植 HATI和 PTI共 32枚 ,在术后 3个月和 6个月处死动物取材。应用组织学、定量组织学、推出试验、扫描电镜等方法 ,观察种植体骨界面的结合情况和剪切强度。 结果 :HATI与 PTI均与骨组织形成了骨性结合 ;HATI的骨性结合率与界面剪切强度均显著高于同期 PTI(P<0 .0 1) ;种植后 6个月 ,HATI的剪切强度达 12 .76 MPa,扫描电镜示种植体骨界面断裂大部分在涂层骨组织界面和涂层内部。结论 :HATI具有良好的生物相容性和生物力学性能 ,是值得进一步研究、并可望试用于临床的种植体。Objective: To evaluate the biocompatibility and bio mechanical of HA sintering coated Ti 75 alloy implant (HATI). Methods: A transcortical implant model was used. A total of 32 implants of HATI and pure titanium implant (PTI) were implanted into bilateral femur of 4 adult mongrel dogs. The animals were killed 3 or 6 months after surgery. The implant bone interfaces were observed by X ray examination, morphological and quantitative histological examination. The shear strength at implant bone interface was examined by push out test, and the failure interfaces were observed by SEM. Results: Osseo intergration was confirmed in the both interfaces of HATI and PTI with bone. The osseo intergration rate and shear strength of HATI were greater than that of PTI at the same period( P <0.01). After 6 months, the shear strength of HATI reached 12.76 MPa, SEM showed the major failure at interfaces of coating bone and within the coating. Conclusion: The results of this study indicate that HATI is biocompatible and has better biomechanics. The HATI is worth further investigating and could be recommended for clinical applications.

关 键 词：羟基磷灰石 种植体 生物相容性 钛-75合金 HATI 

分 类 号：R318.08[医药卫生—生物医学工程] R318.01[医药卫生—基础医学]