血清纤维连接蛋白、电解质及心肌酶谱检测在新生儿缺氧缺血性脑病中的诊疗价值  

The detection value of serum fibronectin, electrolyte and myocardial enzyme in neonatal hypoxic- ischemic encephalopathy

作　　者：杨永朝 

机构地区：[1]山东省阳谷县人民医院儿科,252300

出　　处：《中国医师进修杂志》2012年第36期31-34,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清纤维连接蛋白、电解质及心肌酶谱检测在新生儿缺氧缺血性脑病（HIE）中的诊疗价值。方法选取90例HIE患儿作为观察组，临床程度：轻度28例，中度34例，重度28例；同时选取45例正常足月儿作为对照组。测定并比较两组血清纤维连接蛋白、钾、钠、氯、钙以及心肌酶水平。结果观察组血清纤维连接蛋白水平为（141．23±45．21）g／L，明显低于对照组的（257．51±28．99）g/L，差异有统计学意义（P〈0．05）。随临床程度增加观察组血清钾水平逐渐升高，但与对照组以及观察组不同临床程度间比较差异均无统计学意义（P〉0．05）；血清钠水平逐渐降低，轻、中、重度分别为（130．34±3．22）、（126．67±3．54）、（122．45±2．80）mmol／L，三者间比较差异有统计学意义（P〈0．05），均明显低于对照组的（136．22±6．21）mmol／L，差异有统计学意义（P〈0．05）；血清氯和钙水平逐渐降低，轻度分别为（98．99±2．76）和（0．96±0．26）mmol／L、中度分别为（97．21±3．41）和（0．95±0．28）mmol／L、重度分别为（90．33±3．09）和（0．71±0．18）mmol／L，中度与轻度比较差异无统计学意义（P〉0．05），重度与中度和轻度比较差异有统计学意义（P〈0．05），轻、中、重度血清氯和钙水平均低于对照组的（103．43±3．21）和（1．42±0．01）mmol／L，差异有统计学意义（P〈0．05）。随临床程度增加的观察组天冬氨酸氨基转移酶、乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶MB和羟丁酸脱氢酶水平均逐渐升高，轻度分别为（46．2±12．3）、（432．1±145．2）、（245.3±104．2）、（40．3±7．9）和（374．1±148．2）U／L，中度分别为（84．4±33．1）、（569．3±168．2）、（845．1±498．2）、（112．1±50．4）和（473．8±139．2）U／L，重度分别为（122．1±45．6）、（966�Objective To study the detection value of serum fibroneetin, electrolyte and myocardial enzyme in neonatal hypoxic-isehemic encephalopathy （HIE）. Methods Ninety children with HIE were seleeted as the observation group, among them 28 eases of mild, 34 cases of moderate, 28 cases of serious, i and 45 cases of normal full- term infant were selected as control group. The serum fibronectin, electrolyte and myocardial enzyme of two groups were detected. Results The serum fibronectin level in observation group was significantly lower than that in control group [ （ 141.23±45.21 ） g/L vs. （257.51 ± 28.99） g/L, P 〈 0.05 ]. With clinical degree increased, the serum potassium level in observation group gradually increased, but the difference between control group and observation group, and among different clinical degree of observation group were not statistically significant （P 〉 0.05）. The serum sodium level gradually reduced,there were significant differences among mild, moderate, serious [ （ 130.34 ± 3.22）, （ 126.67 ± 3.54） and （ 122.45 ± 2.80） mmol/L, respectively, P 〈 0.05 ], they were significantly lower than control group [ （ 136.22 ± 6.21 ） mmol/L,P 〈 0.05]. The serum chlorine and calcium levels gradually reduced,mild were （98.99 ± 2.76） and （0.96 ±0.26） mmol/L,moderate were （97.21 ±3.41） and （0.95 ±0.28） mmol/L,and serious were （90.33 ± 3.09） and （0.71 ± 0.18） mmol/L,there was no significant difference between moderate and mild （P 〉 0.05 ）, serious were significantly lower than those in mild and moderate （P 〈 0.05 ）. The serum chlorine and calcium levels in mild,moderate and serious were significantly lower than those in control group [（103.43 ±3.21） and （1.42 ±0.01） mmol/L,P 〈0.05]. With clinical degree increased,the aspartate aminotransferase,lactate dehydrogenase, creatine kinase, creatine kinase isozyme MB and hydroxyl butyrate dehydrogenase levels in observation group gradually increased, mild were （46.2 ± 1

关 键 词：缺氧缺血 脑 连接蛋白类 电解质 心肌酶谱 

分 类 号：R722.1[医药卫生—儿科]