^(13)C-混合甘油三酯呼气试验测定胰腺外分泌功能的研究  

Study of ^(13)C labelled mixed triglyceride breath test for assessing pancreatic exocrine function

作　　者：黄留业[1] 刘运祥[1] 吴承荣[1] 崔俊[1] 于洪[1] 刘一品[1] 周福润 仪德亮[1] 宋波[1] 

机构地区：[1]山东烟台毓璜顶医院消化内科,山东烟台264000

出　　处：《中国医学工程》2012年第12期3-4,共2页China Medical Engineering

基　　金：烟台市科技发展计划资助(2008142-3)

摘　　要：目的测定慢性胰腺炎患者13C-混合甘油三酯呼气试验,了解对胰腺炎患者胰腺外分泌功能检测的临床意义。方法 A组35例正常志愿者为对照,20例无脂肪泻慢性胰腺炎患者为B组,20例有脂肪泻慢性胰腺炎患者为C组,进食13C-混合甘油三酯后,检测呼气中13CO2,评估胰腺的外分泌功能。C组患者补充胰酶后再行13C-混合甘油三酯试验。结果 C组13C-混合甘油三酯呼气试验显示,13C峰值(PDRpeak)和6h呼出13C累积丰度(cPDR)较A组明显降低[(1.63±0.25)%Vs(2.93±0.52)%;(6.83±0.62)%Vs(12.11±1.35)%;P<0.01],补充胰酶后PDRpeak和cPDR/6h较治疗前明显升高[(2.35±0.32)%,(8.82±0.72)%;P<0.01],但cPDR/6h低于正常对照组(P<0.05);B组PDRpeak和cPDR/6h与对照组无明显差异。13C通常在(6.12±1.32)h达到PDRpeak峰值。结论13C-混合甘油三酯能有效地检测胰腺外分泌功能和了解胰酶治疗的疗效。【Objective】To assess the exocrine pancreatic function by the 13C labelled mixed triglyceride breath test.【Methods】 Group A consisted of 35 volunteers without pancreatic diseases served as controls.40 patients were chronic pancreatitis（CP）.Group B consisted of 20 chronic pancreatitis patients without steatorrhea and group C consisted of 20 chronic pancreatitis patients with steatorrhea.The 13C labeled mixed triglyceride breath test and faecal fat to monitor exocrine pancreatic function were performed.After having been treated with enzyme replacement,patients in group C were performed the breath test again.【Resluts】After administered 13C labelled mixed triglyceride together with a fixed pudding,the dosage of 13C/ h maximal PDR（PDRpeak） and cumulative percent dosage of 13C recovery per 6 h（cPDR/ 6 h） in group A were significantly higher than that in group C[（1.63±0.25） % vs.（2.93±0.52）%;（6.83±0.62） % vs.（12.11±1.35）%;P0.01],respectively.Group C patients were given repeated tests after pancreatic enzyme supplementation and showed significantly rise of PDRpeak and cPDR/6h [（2.35±0.32） %,（8.82±0.72） %;P0.01],but cPDR/ 6 h was lower than that of controls（P0.05）.The PDRpeak and cPDR in group B patients had no difference from group A.The time of PDRpeak was（6.12±1.32）h in group B.【Conclusion】In patients with chronic pancreatitis,the 13C labelled mixed triglyceride breath test reflects the fat metabolism and monitors the therapentic efficacy of pancreatic enzymes.

关 键 词：慢性胰腺炎 胰腺功能 呼气试验 混合甘油三酯 

分 类 号：R657.51[医药卫生—外科学]