银杏叶提取物对大鼠高血压、高血糖合并高脂血症的治疗作用  

Effects of Ginkgo biloba Extract on Hypertension,Hyperglycemia and Hypercholesterolemia in Rats

作　　者：鲁茜[1] 汪建云[1] 羊倩倩[2] 张明珠[2] 尹家乐[2] 印晓星[1] 

机构地区：[1]徐州医学院药学院临床药理学教研室,江苏徐州221004 [2]徐州医学院药学院新药与临床应用实验室,江苏徐州221004

出　　处：《药学与临床研究》2012年第6期485-489,共5页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金资助项目(81173104);江苏高校优势学科建设工程资助项目(PAPD);江苏省高校自然科学基金项目(09KJD310011)

摘　　要：目的:观察银杏叶提取物对大鼠高血压、高血糖合并高脂血症的治疗作用。方法:成年雄性自发性高血压大鼠(SHR)高糖高脂饲料喂养4周后,给予小剂量链脲佐菌素35 mg·kg-1腹腔注射诱导制备高血压、高血糖合并高脂血症大鼠模型。给予银杏叶提取物治疗,8周后测定大鼠血压、血糖、糖化血红蛋白、血脂及血清中抗氧化指标及丙二醛水平。结果:银杏叶提取物治疗后,大鼠血压、空腹血糖、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白及丙二醛水平均较模型组显著下降,高密度脂蛋白和抗氧化酶活性则显著升高。结论:银杏叶提取物能够降低高血压、高血糖合并高脂血症大鼠的血压、血糖和血脂,并增强其机体抗氧化能力,对高血压、高血糖合并高脂血症具有一定的治疗作用。Objective： To observe the prophylatic and therapeutic effects of Ginkgo biloba extract （GBE） on hypertension, hyperglycemia and hypercholesterolemia in rats. Methods： Adult spontaneously hypertensive rats （SHR） were fed with high-fat and high-sugar diet for four weeks, and then received intraperitoneal injection of streptozotocin once in a dose of 35 mg·kg-1 to induce the model of hypertension, hyperglycemia and hypercholesterolemia. After treatment with GBE for 8 weeks, blood samples were collected. Blood pressure and blood levels of glucose, glycosylated hemoglobin （HbA1C）, total cholesterol, triglyeride, low density lipoprotein （LDL-C）, high density lipoprotein （HDL-C）, antioxidase and malonaldehyde （MDA） were measured. Results： After the treatment of GBE, blood pressure and blood levels of glucose, HbA1C, total cholesterol, triglyeride, LDL-C and MDA were significantly lowered, the HDL levels and antioxidase activities were greatly enhanced when compared with those of the model group. Conclusion： GBE has effects of anti-oxidation and MDA lowering, and thus has therapeutic effects on blood pressure and blood levels of sugar, total cholesterol and triglyeride. Therefore, GBE has preventive and protective effects on hypertension, hyperglycemia and hypercholesterolemia.

关 键 词：银杏叶提取物 高血压 高血糖 高血脂 

分 类 号：R965.1[医药卫生—药理学]