艾司洛尔与洋地黄控制房颤心室率的疗效比较分析  

Efficacy Comparison of Esmolol and Digitalis on Ventricular Rate Controlling in Atrial Fibrillation

作　　者：马超[1] 

机构地区：[1]江西省赣州市人民医院,赣州341100

出　　处：《药学与临床研究》2012年第6期549-550,共2页Pharmaceutical and Clinical Research

摘　　要：比较静注艾司洛尔和洋地黄对房颤的疗效。结果:静注艾司洛尔组(40例)起效快(0～5 min),有效率高(92.5%),副作用发生率低(2.5%),静息和运动时心室率减慢。口服洋地黄组(40例)起效慢(20～30 min),有效率低(75.0%),副作用发生率高(15%)。Objective： To compare the efficacies of esmolol and digitalis on controlling ventricular rate in atrial fibrillation （AF）. Methods： A total of 80 patients with atrial fibrillation were randomly divided into esmolol group （n=40） and digitalis group （n=40）. In the esmolol group, esmolol was injected intravenously; in the digitalis group, cedilanid 0.4 mg was injected intravenously, after the onset, oral digoxin 0.125~0.25 qd was followed. The onset time and the controlling of ventricular rate at rest and exercise were observed. Results： The onset times in esmolol group and digitalis group were immediate ~5 min and 20~30 min, respectively, the total effective rates were 92.5% and 75.0%, respectively （P〈0.05）. The efficacies of the two groups were significantly different （P〈0.01）, with esmolol being better than digitalis. The incidences of adverse events were 2.5% and 15%, respectively. Conclusion： In the absence of severe cardiac dysfunction, esmolol is superior to digitalis with rapid onset and less obvious side effects on controlling ventricular rate in atrial fibrillation at rest and activity.

关 键 词：房颤心室率 艾司洛尔 洋地黄 

分 类 号：R969.4[医药卫生—药理学]