腺性膀胱炎动物模型不同治疗方法的效果分析  

Analysis on the effect of treatments for the glandular cystitis animal models

作　　者：易憬[1] 熊飞[2] 苏良平[1] 陈登[1] 杨兵[1] 张盛龙[1] 张宝珍[1] 刘长[1] 易文龙[3] 

机构地区：[1]武汉钢铁(集团)公司大冶铁矿职工医院,湖北黄石435006 [2]华中科技大学同济医学院计划生育研究所,湖北武汉430030 [3]武汉科技大学附属天佑医院,湖北武汉430064

出　　处：《东南国防医药》2012年第6期514-516,共3页Military Medical Journal of Southeast China

摘　　要：目的探讨腺性膀胱炎的最佳治疗方法。方法 40只成年雌性健康SD大鼠,其中35只建成腺性膀胱炎动物模型,随机分为生理盐水对照组5只(A组)、抗感染组10只(B组)、托特罗定组10只(C组)、抗感染+托特罗定组10只(D组)进行研究,在治疗前和开始治疗后两周均给予尿动力学检查。另外5只不做任何处理,作正常对照组(E组),在和动物模型相同的时间点给予两次尿动力学检查。结果正常对照组与治疗后的生理盐水对照组、抗感染组、托特罗定组的排尿压和最大膀胱容量有显著性差异(P<0.05),正常对照组与治疗后抗感染+托特罗定组的排尿压和最大膀胱容量无显著性差异(P>0.05),治疗后的生理盐水对照组与抗感染组、托特罗定组的排尿压和最大膀胱容量有显著性差异(P<0.05),治疗后的抗感染组、托特罗定组与抗感染+托特罗定组的排尿压和最大膀胱容量有显著性差异(P<0.05)。结论抗感染与托特罗定共同治疗腺性膀胱炎动物模型,有较好的效果。Objective To explore the better treatment for glandular cystitis. Methods 40 adult female SD rats were divided into 5 groups randomly （5 in physiological saline control group,10 in anti-infection treatment group, 10 in toherodine treatment group, 10 in anti-infection combined with tolterodine treatment group, other 5 in normal control group without any treatment）. The urodynamic parameters were evaluated before the treatment and two weeks after the treatment. Results After two weeks treatment, there were significant difference in the voiding pressure and maximum bladder capacity among normal control group, physiological sa- line control group, anti-infection treatment group, and toherodine treatment group （ P 〈 0.05 ）. There is no sig- nificant difference in the voiding pressure and maximum bladder capacity between normal control group and antiinfection combined with toherodine treatment group post-treated （ P 〉 0.05 ）. There was significant difference in the voiding pressure and maximum bladder capacity between physiological saline control group and anti-infection treatment group, toherodine treatment group post-treated （ P 〈 0.05 ）. There were significant difference in the voiding pressure and maximum bladder capacity amonganti-infection combined with tolterodine treatment group, anti-infection treatment group and toherodine treatment group （ P 〈 0.05 ）. Conclusion Antibiotics combined with tolterodine can effectively improve urodynamic parameters of cystitis glandularis animal models.

关 键 词：腺性膀胱炎 托特罗定 排尿压 最大膀胱容量 

分 类 号：R694.3[医药卫生—泌尿科学]