紫丁香叶的化学成分研究  

Chemical Constituents of Syringa oblata Leaves

作　　者：田雷[1] 李永吉[1] 吕邵娃[1] 张亮[1] 刘婷[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040

出　　处：《中国实验方剂学杂志》2013年第1期144-147,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对木犀科丁香属植物紫丁香叶的化学成分进行研究。方法:采用硅胶柱色谱法、重结晶及制备高效液相色谱等技术提取分离,利用紫外(UV)、红外(IR)、质谱(EI-MS)、核磁共振(1H-NMR,13C-NMR)、异核多量子关系谱(HMQC)及多键碳氢关系谱(HMBC)等光谱方法鉴定化合物结构。结果:分析并鉴定了9个化合物的结构:(+)松脂素-4″-O-β-D-葡萄吡喃糖苷(1),(+)表松脂素-4-O-β-D-葡萄糖苷(2),落叶松脂醇-4-O-β-D-葡萄吡喃糖苷(3),3,4∶3',4'-bis(methylene-dioxy)-9'-hydroxyl-lignane-9-methyl-O-β-D-葡萄吡喃糖苷(4),2-(3,4-dihydroxyphenyl)ethyl(1R,4aS,8R,8aS)-8-methyl-6-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy)oxan-2-yl]oxy-4a,5,8,8a-tetrahydro-1H-pyrano[3,4-c]pyran-4-carboxylate(5),3,4-二羟基苯乙二醇(6),对羟基苯乙醇(7),6-O-(E)-feruloyl-(α)-glucopyranoside(8),6-O-(E)-feruloyl-(β)-glucopyranoside(9)。结论:化合物1～6为首次从该植物分离得到的化合物。Objective： To investigate the chemical compositions of the leaves of Syringa oblata. Method： The separation was performed by using silica gel column chromatography, recrystallization and the HPLC preparation methods. The compound structures were identified according to the spectral analytical methods UV, IR,1H-NMR,13C-NMR, HSQC and HMBC. Result： The structures of the nine compounds were fully determined by the chemical and physicochemical evidences. They were （ ＋ ） pinoresinol-4″-O-β-D-glucopyranoside （1）. lariciresinol-4-O-β-D-glucopyranoside （2）. （ ＋ ） epipinoresinol-4-O-β-D-glucopyranoside （3）. 3, 4： 3′, 4′bis （methylene-dioxy） -9′-hydroxyl-lignane-9-methyl-O-β-D-glucopyranoside （4）. 2- （3, 4-dihydroxyphenyl） ethyl （ 1R, 4aS, 8R, 8aS ） -8-methyl-6-oxo-1- [ （ 2S, 3R, -4S, 5S,. 6R ） -3, 4, 5-trihydroxy-6- （hydroxymethy） oxan-2-yl ] oxy-4a, 5, 8, 8a-tetrahydro-lH-pyrano [ 3, 4-c ] pyran-4-carboxylate （5）. 3, 4-dihydroxybenzene-Styrene glycol （6）. 4-hydroxyphenethyl alcohol （7）. 6-O- （E） -ferutoyl- （α） -glucopyranoside （8）. 6-O- （E） -feruloyl- （β） -glucopyranoside （9）. Conclusion： All of the constituents are obtained in leaves of S. oblata; among them, compounds 1-6 are reported in this species for the first time.

关 键 词：紫丁香 化学成分 木脂素苷 环烯醚萜苷 

分 类 号：R284.1[医药卫生—中药学]