丹参水煎剂外用对大鼠及小鼠烫伤模型的影响  

Effect of water solution of Radix Salviae Militiorrhizae in external application on rat and mouse scald model

作　　者：梁雪[1] 闫欣[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中华中医药杂志》2013年第1期56-59,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金："十一五"国家科技支撑计划(No.2008BAI53B09);郑州市科技攻关(No.10PTGS485-21)~~

摘　　要：目的:探讨丹参水煎剂外用对大鼠及小鼠烫伤模型的影响。方法:背部皮肤浸入90℃恒温水浴中持续6s,造小鼠烫伤模型;背部皮肤浸入80℃恒温水浴中持续10s,造大鼠烫伤模型;观察大、中、小剂量丹参水煎剂对大鼠及小鼠烫伤面积及局部病理变化的影响。结果:两种模型建立成功,丹参水煎剂可显著减少小鼠烫伤面积,显著增加大鼠烫伤面积纸重差值,显著改善各模型动物烫伤局部的组织病理学变化。结论:丹参水煎剂外用对大鼠及小鼠烫伤模型均有较好的治疗作用。Objective： To investigate the effect of water solution of Radix Salviae Militiorrhizae on rat scald model and mouse scald model.Methods： By keeping the dorsum skin of mouse in 90℃ hot water for 6 seconds to establish the mouse scald model;while keep in 80℃ hot water for 10 seconds to establish the rat scald model;observing the effect of water solution of Radix Salviae Militiorrhizae of different dose on scald area and pathological changes.Results： The scald model of mouse and rat were totally successfully established;the water solution of Radix Salviae Militiorrhizae could significantly reduce the scald area of mice,and significantly increase the weight of sulfuric acid paper which used to describe the scald area,and at the same time significantly repair the pathological injury on local skin of each model group.Conclusion： The water solution of Radix Salviae Militiorrhizae in external application has positive effect on curing the local skin of rat scald model and mouse scald model.

关 键 词：丹参水煎剂 外用 烫伤 

分 类 号：R285.5[医药卫生—中药学]