益肺活血颗粒对慢性肺源性心脏病家兔肺组织细胞增殖的影响  

Influence of Yifei Huoxue Particles on lung tissue cell proliferation in chronic pulmonary heart disease in rabbits

作　　者：翟华强[1,2] 金平华[1] 詹雪艳[1] 汪小惠[1] 张硕峰[1] 袁园[1] 欧敏[3] 

机构地区：[1]北京中医药大学,北京100102 [2]北京师范大学资源生态与中药资源研究所,北京100875 [3]海军总医院,北京100037

出　　处：《中华中医药杂志》2013年第1期203-205,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金："十一五"军队课题(No.2006083001);北京市自然科学基金(No.7102097)~~

摘　　要：目的:观察益肺活血颗粒对慢性肺源性心脏病家兔肺组织细胞的增殖影响,探讨其对肺动脉血管内皮的损伤的保护作用机制。方法:采用0.7%FeCl3溶液耳缘静脉注射造模方法建立肺血管损伤家兔模型,随机设立正常组、模型组、卡托普利组及益肺活血颗粒组,每组8只,卡托普利组、益肺活血颗粒组分别给予卡托普利片、益肺活血颗粒,共42d,观察肺组织细胞的增殖情况。结果:模型组流式细胞S%值与正常组相比明显降低(P<0.05);益肺活血颗粒组与模型组相比,S%值显著增高(P<0.05);卡托普利组与模型组相比,差异无统计学意义。结论:益肺活血颗粒可以使细胞增殖恢复正常,保证受损细胞能够自我修复,消除肺心病患者长期存在的病理状态。Objective： To study the influence of Yifei Huoxue Particles（YFHX）on lung tissue cell proliferation in the chronic pulmonary heart disease（CPHD）in rabbits.Methods： A total of 32 rabbits were randomly divided into 4 groups（normal group,model group,the captopril group,YFHX group）,8 rabbits in each group.the rabbits in model group,the captopril group and YFHX group were modeled using 0.7% FeCl3 by ear vein injection.A total of 42 days,the rabbits in the captopril group and YFHX group were given captopril and YFHX accordingly,in order to observe the lung tissue cell proliferation.Results： Compared with the normal group,the flow-cytometry S% of model group showed significantly decrease（P0.05）;Compared with the model group the flow-cytometry S% of YFHX group showed significant increse（P0.05）,but there was no significant difference between captopril group and model group of S%.Conclusion： Yifei Huoxue Particles can make the blood cells back to normal,to ensure that damaged cells to self-repair,and eliminate pulmonary heart disease patients with long-standing pathological state.

关 键 词：益肺活血颗粒 慢性肺源性心脏病 血管损伤 细胞增殖 家兔 

分 类 号：R285[医药卫生—中药学]