氯硝柳胺乙醇胺盐喷雾剂的研究Ⅱ预防耕牛日本血吸虫感染效果的现场观察  

Studies on spray of niclosamide ethanolamine salt Ⅱ Observation on prevention of Schistosoma japonicum infection in bovine

作　　者：戴建荣[1] 邢云天[1] 李洪军[1] 汪伟[1] 陶永辉[1] 宁安 高袓禄 吴有彩 王美龙 梁幼生[1] 

机构地区：[1]江苏省血吸虫病防治研究所、卫生部寄生虫病预防与控制技术重点实验室、农业部杀虫剂药效评价中心,无锡214064 [2]江西省寄生虫病防治研究所 [3]江西省永修县吴城镇畜牧兽医站 [4]江西省永修县吴城镇血吸虫病防治站

出　　处：《中国血吸虫病防治杂志》2012年第6期636-639,共4页Chinese Journal of Schistosomiasis Control

基　　金：国家科技支撑计划(2009BAI78B06);国家自然科学基金(81071379);江苏省医学领军人才项目(LJ2011032)

摘　　要：目的现场观察氯硝柳胺乙醇胺盐喷雾剂预防耕牛日本血吸虫感染的效果,为实施以传染源控制为主的血吸虫病综合防治策略提供技术支撑。方法以血吸虫病流行区江西省永修县吴城镇160头耕牛为实验对象,对实验耕牛逐一编号,收集牛粪采用顶管孵化法检查耕牛血吸虫感染情况。在给予吡喹酮治疗后,全部粪检阴性实验耕牛随机分成A、B、C 3组:A组每隔15 d采用氯硝柳胺乙醇胺盐喷雾剂对耕牛全身喷药1次,剂量为每次500 ml/头;B组每隔30 d采用氯硝柳胺乙醇胺盐喷雾剂对耕牛全身喷药1次;C组为对照组,每隔15 d采用不含氯硝柳胺乙醇胺盐的空白剂对耕牛喷药1次。试验期间,每隔30 d采用顶管孵化法检查全部试验耕牛血吸虫感染情况。结果持续喷药90 d后,喷药组A、B及对照组耕牛血吸虫病患病率分别为4.00%、4.08%和24.49%;与对照组相比,喷药组A和喷药组B耕牛血吸虫病患病率分别下降83.67%和83.34%。结论采用氯硝柳胺乙醇胺盐喷雾剂对耕牛进行全身喷药可预防耕牛感染日本血吸虫,降低耕牛血吸虫病患病率。Objective To investigate the spray of niclosamide ethanolamine salt on prevention of bovine schistosomiasis in the field so as to provide a technical support for the improvement of schistosomiasis control strategy.Methods A total of 160 buffalo were selected as experimental objects marked by ear-mark numbers.All the buffalo were administered with praziquantel and then randomly divided into 3 groups,which were sprayed with niclosamide ethanolamine salt（500 ml per head） every 15 d（Group A）,every 30 d（Group B） and an agent without niclosamide ethanolamine salt every 15 d（Group C as the control）,respectively.The buffalo＇s droppings were collected to examine the eggs of schistosome every 30 days during the trial.Results Ninety days after the spraying,the prevalence rates of schistosomiasis were 4.00%,4.08%,and 24.49% in the Group A,Group B,and Group C,respectively.Compared with the control group（Group C）,the decline prevalence rates of schistosomiasis were 83.67% and 83.34% in the Group A and Group B,respectively.Conclusions The buffalo spraying with 1% niclosamide ethanolamine salt can reduce schistosomiasis prevalence in bovine,that is this intervention has an obvious protective effect.

关 键 词：氯硝柳胺乙醇胺盐 喷雾剂 日本血吸虫 耕牛 预防效果 

分 类 号：R383.24[医药卫生—医学寄生虫学]