滥用海洛因和口服可待因者尿液中吗啡和可待因的比较  

Comparison of Morphine and Codeine Concentration in Urines of Heroin Abusers and Codeine Users

作　　者：卜俊[1] 展长淑[2] 

机构地区：[1]司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海200063 [2]苏州大学医学部法医学系,江苏苏州215123

出　　处：《法医学杂志》2012年第6期426-428,共3页Journal of Forensic Medicine

基　　金：科研院所社会公益研究专项(GY0807)

摘　　要：目的比较滥用海洛因和口服可待因者尿液中吗啡及可待因的质量浓度,探讨区分海洛因滥用和口服可待因者的判断指标。方法滥用海洛因和口服可待因者在不同时间点收集尿液,尿液经蛋白沉淀法处理后,用超高效液相色谱-串联质谱法(UPLC-MS/MS)进行定性定量分析,对测得结果进行统计分析。结果滥用海洛因和口服可待因者尿液中吗啡和可待因质量浓度的样本分布均为非正态分布。当吗啡质量浓度大于67ng/mL时,滥用海洛因概率大于95%,同时口服可待因的概率小于5%;当吗啡质量浓度小于67 ng/mL时,口服可待因的概率大于95%,同时滥用海洛因概率小于5%。结论以尿液中吗啡质量浓度能区分滥用海洛因和口服可待因者,而以可待因质量浓度则无法区分滥用海洛因和口服可待因者。Objective To compare morphine and codeine concentration in urines of heroin abusers and codeine users and to discuss the judgment index to distinguish between heroin abuser and codeine user. Methods The urines of heroin abusers and codeine users were collected at different time periods. After protein precipitation, the urine samples were conducted for the qualitative and quantitative analysis of morphine and codeine by UPLC-MS/MS. And the results were all statistically analyzed. Results Statistical analysis showed that morphine and codeine concentration in urines of heroin abusers and codeine users were both abnormal distributions. The probability of the heroin abuser would be more than 95% and less than 5% for the codeine user when the concentration of morphine in urine sample was more than 67ng/mL. The probability of the codeine user would be more than 95% and less than 5% for the heroin abuser when the concentration of morphine in urine sample was less than 67 ng/mL. Conclusion The morphine concentration in urine could be used as a criterion to distinguish the heroin abuser from the codeine user, while the codeine concentration could not.

关 键 词：法医毒理学 吗啡 可待因 海洛因 超高效液相色谱-串联质谱法 

分 类 号：R595.505[医药卫生—内科学]