地佐辛与舒芬太尼预防阑尾切除术内脏牵拉反应效果的比较  

Comparison on effects of Dezocine and Sufentanil in preventing visceral traction in appendectomy

作　　者：陈明富[1] 张干[2] 李胜利[1] 刘安林[1] 黄波[1] 陈爱文[1] 伍捡林[1] 易红艳[1] 

机构地区：[1]广州医学院附属深圳沙井医院麻醉科,广东深圳518104 [2]深圳市宝安区人民医院麻醉科,广东深圳518101

出　　处：《临床军医杂志》2012年第6期1381-1382,共2页Clinical Journal of Medical Officers

摘　　要：目的观察地佐辛与舒芬太尼静脉辅助用药预防硬膜外麻醉下阑尾切除术中内脏牵拉反应的效果及安全性。方法将40例拟行阑尾切除术的ASAⅠ～Ⅱ级患者,随机分为地佐辛组(D)和舒芬太尼组(S),每组20例。经T11～12椎间隙行硬膜外穿刺置管,麻醉平面固定后,切皮前D组静注地佐辛0.1 mg/kg,S组静注舒芬太尼0.2μg/kg。两组均不吸氧。记录用药前后SPO2变化及牵拉腹膜、阑尾,擦拭腹腔时的牵拉痛、恶心呕吐等不良反应,并评估二者预防内脏牵拉反应的效果及安全性。结果 D组及S组预防内脏牵拉反应的效果均良好,两组比较,差异无统计学意义(P>0.05),用药后5 min S组患者的SPO2低于D组(P<0.05)。结论地佐辛与舒芬太尼预防内脏牵拉反应的效果良好,且作用相当,但地佐辛的呼吸抑制作用轻,相对安全。Objective To observe the efficacy and safety in preventing visceral traction between Dezocine and Sufentanil intravenous auxiliary in appendectomy during continuous epidural anesthesia. Methods Forty cases of ASAⅠ~Ⅱ were randomly divided into Dezocine group（D） and Sufentanil group（S） with 20 cases each.The T11~12 intervertebral epidural puncture and catheterization were performed,after anesthesia fixed and before cutting skin,Dezocine 0.1mg/kg and Sufentanil 0.2μg/kg were injected in group D and in group S by intravenous respectively.None in two groups received oxygen inhalation therapy.SPO2 changes and adverse reactions before and after treatment such as referred pain after pulling peritoneum,appendix,wiping abdominal space and nausea and vomiting were recorded.The efficacy and safety of them in prevention of visceral traction were assessed. Results Both Group D and S had well effects in preventing visceral traction（P0.05）,5 minutes after administration,SpO2 in group S was lower than in Group D（P0.05）. Conclusion Both Dezocine and sufentanil have well and similar effects in preventing visceral traction,but Dezocine has less respiratory depression and relatively safe.

关 键 词：地佐辛 舒芬太尼 硬膜外麻醉 牵拉反应 阑尾切除术 

分 类 号：R971.2[医药卫生—药品]