阿托伐他汀对于肥胖人群颈动脉斑块干预作用的研究  

Effect of Atorvastatin on carotid artery plaque in patients with obesity populations

作　　者：叶盛开[1] 安伶[1] 陈海英[1] 温洁[1] 朱爽[1] 任霞[1] 杜颖[1] 

机构地区：[1]解放军第210医院肾脏内分泌科,辽宁大连116021

出　　处：《临床军医杂志》2012年第6期1434-1435,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨阿托伐他汀对于肥胖人群血脂及颈动脉斑块的影响。方法 39例肥胖者给予阿托伐他汀20 mg,1次/晚,用药前及用药后间隔14周,观察血脂及颈动脉斑块的变化。结果经过阿托伐他汀治疗后,受试者血清总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)水平均较治疗前有明显降低(P<0.05或P<0.01),而高密度脂蛋白胆固醇(HDL-C)变化不明显(P>0.05)。经阿托伐他汀治疗后,受试者颈动脉斑块大小、斑块厚度、斑块数量均有明显改善(P<0.05或P<0.01)。结论阿托伐他汀不但可降低肥胖者的血清TC、TG和LDL-C水平,逆转了动脉粥样斑块的发生、发展,有助于减少远期心脑血管并发症的风险,改善生活质量。Objective To investigate the effect of Atorvastatin on carotid artery plaque in patients with obesity populations. Methods Thirty nine obesity cases were given Atorvastatin 20 mg every night for 14 weeks.The changes of their blood lipid and carotid artery plaque were observed. Results After Atorvastatin administration,the serum total cholesterol（TC）,triglyceride（TG） and low density lipoprotein cholesterol（LDL-C） decreased significantly compared to that before treatment（P0.05 or P0.01）,while there was no apparent change of high density lipoprotein cholesterol（HDL-C）（P0.05）.The carotid artery plaque area,thickness and amounts all improved significantly after treatment（P0.05 or P0.01）. Conclusion Atorvastatin can reduce the level of serum TC,TG and LDL-C in obesity populations,but also reverse the occurrence and development of carotid artery plaque,decrease the long-term cerebro-cardiovascular complications,and improve obesity populations＇ quality of life.

关 键 词：阿托伐他汀 肥胖人群 颈动脉斑块 

分 类 号：R543.5[医药卫生—心血管疾病]