早产儿早期微量喂养和胃肠外营养相关胆汁淤积的关系探讨  

Analysis on relationship between early minimal feeding of premature and parenteral nutrition associated cholestasis

作　　者：许波[1] 王曼秋[1] 曹艳华[1] 

机构地区：[1]解放军济南军区总医院儿科,山东济南250031

出　　处：《临床军医杂志》2012年第6期1477-1479,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨早产儿早期微量喂养在减少胃肠外营养相关胆汁淤积(PNAC)方面的可行性、有效性。方法选择2008年1月—2011年6月住我科新生儿监护病房低体质量早产儿56例,随机分为静脉营养加微量喂养组(观察组)和静脉营养组(对照组),每组各28例,于第1、第14天分别检测总胆汁酸、肝功能等。结果静脉营养前,观察组和对照组总胆汁酸、黄疸程度、肝损害程度无明显差异(P>0.05);而静脉营养14 d后,对照组总胆汁酸、黄疸程度、肝损害程度均较观察组明显升高(P<0.01)。观察组发生胃肠外营养相关胆汁淤积的例数明显低于对照组(P<0.05);两组在发生不良反应方面无明显差异(P>0.05)。结论尽早开始胃肠内微量喂养可降低早产儿静脉营养所致总胆汁酸、黄疸、肝功损害程度升高的危险,可减少PNAC的发生率。Objective To study the probability in decreasing parenteral nutrition associated cholestasis（PNAC） of early minimal feeding on the nutrition of premature. Methods Fifty-six low birth weights premature were enrolled in this study between January 2008 and June 2011.The infants were divided into two groups randomly,28 cases with intravenous nutrition and early minimal feeding as observe group,28 cases with intravenous nutrition as control group.The total bile acids,function of liver and so on were detected in the first and fourteenth day. Results There were no significant difference in the total bile acids,icterus indexes and hepatic lesion levels between the two groups before intravenous nutrition（P0.05）,but there were significant difference after 14d of intravenous nutrition（P0.01）.The incidence with PNAC of the observe group were lower compared with the control group（P0.05）.There was no significant difference in complication between the two groups（P0.05）. Conclusion Early minimal feeding could reduce the occurrence of complications of intravenous nutrition,reduce the incidence of the PNAC.

关 键 词：胃肠外营养 胆汁淤积 

分 类 号：R722[医药卫生—儿科]