活性氧化镁降氟水对小鼠精子形态的影响  

Effect of water defluoridation by activated magnesia on sperm morphology in mice

作　　者：吕严[1] 孙增荣[1] 吴丽娜[1] 于德奎[1] 

机构地区：[1]天津医科大学环境卫生教研室,天津300070

出　　处：《中国地方病防治》2000年第3期137-138,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的本文通过研究活性氧化镁（一新型降氟剂）降氟水对小鼠精子形态的影响，从一个侧面来评价其岁全性。方法昆明种小鼠２０只，随机分为５组。２组饮用活性氧化镁降氟水（镁离子浓度分别为３６０ｍｇ／Ｌ和１８０ｍｇ／Ｌ），２组饮用高氟水（１００ｍｇ／Ｌ和５０ｍｇ／Ｌ），另设１个对照组。对小鼠进行６个月的饮水实验。结果与对照组比，饮用活性氧化镁降氟水的小鼠精子畸形率则未见增高（Ｐ＜０．０５），而饮用高氟水的小鼠精子畸形率均明显增高（Ｐ＜０．０１）。结论饮用高氟水可诱发小鼠精子畸形。长期饮用活性氧化镁降氟水未见对小鼠精子形态的不良影响。Objective In order to evaluate the safety of drinking water defluorodation by activated magnesia (a new defluorination agent) sperm aberration test of 6 months via drinking water defluorinated in mice was carried out. Method 20 mice were random divided into 5 groups: 2 groups of drinking defluorodation water (Mg 360mg/L, 180mg/L), 2 groups of drinking high fluoride water (F 100mg/L, 50mg/L)and a control group drink ing microfluoride tap water (F 0. 50mg/L). The morphology of sperm were tested in thee after drinking defluoroda- tion water and the water of high fluoride. Result Compared with control group the sperm aberration rates were not founded significantly changes (P> 0. 05) in groups of drinking defluorodated wate and significantly increase in mice of high fluoride groups(P <0. 01 ). Conclusion The sperm aberration rate of mice were significantly in- crease after drinking high fluoride water, but no adverse effects of defluorodated drinking water on sperm morpholo- gy were noticed.

关 键 词：活性氧化镁 精子畸形 氟中毒 降氟水 生物学效应 

分 类 号：R599.9[医药卫生—内科学]