不同浓度碘离子诱发小鼠甲状腺肿的实验研究  

The mice goiter induced by different iodine ion water

作　　者：李英华[1] 朱惠民[1] 刘福英[2] 董少霞[1] 张建军[1] 王彦娜[3] 郭影[4] 

机构地区：[1]河北医科大学环境卫生学教研室,石家庄050017 [2]河北医科大学实验动物学部,石家庄050017 [3]河北医科大学校门诊部,石家庄050017 [4]河北医科大学附属三院,石家庄050017

出　　处：《中国地方病防治》2000年第3期139-140,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的　本实验用不同浓度碘水诱发小鼠高碘甲状腺肿。方法将实验动物随机分为５组，分别饮含碘５０、５００、１０００、２０００、３０００μｇ／Ｌ的去离子水。喂至３月龄，观察小鼠甲状腺和血清学变化。结果碘离子５００μｇ／Ｌ就可诱发小鼠高碘甲状腺肿。随着碘离子浓度的升高甲状腺绝对重量和相对重量有增大趋势。光镜观察，甲状腺肿为胶质性甲状腺肿。血清学改变为，Ｔ４、ｒＴ３升高，Ｔ３变化不明显。随着碘浓度的升高，Ｔ４、ｒＴ３有升高趋势，但无统计学意义。结论　碘离子浓度达到５００μｇ／Ｌ时，就可诱发高碘甲状腺肿。Objective To induce the mice goiter in different iodine water. Method The study was divid- ed into5 groups by randomized. The mouse drank 50, 500 1000, 2000 and 500 ug/L, the mice goiter was found. With the iodine ion increased, the absolute weight and relative weight of thyroid were also increased.The serum T4.rT3 in 2nd, 3rd, 4th, 5th group were higher then that of the first group. With the iodine ion increased, the serum T4.rT3 increased. Conclusion 500 ug/L iodine ion water could induce the mice goiter.

关 键 词：碘离子浓度 甲状腺肿 实验研究 流行病变 

分 类 号：R581.3[医药卫生—内分泌]