小肠移植术后肠内营养因素对FK506血药浓度的影响  

Effect of internal nutrition on the FK506 blood drug concentration after small intestine transplantation

作　　者：赵京霞[1] 王为忠[1] 宋维亮[1] 吴国生[1] 罗宁宁[1] 陈新莉 徐菊丽[1] 

机构地区：[1]第四军医大学西京医院胃肠外科,陕西西安710033

出　　处：《第四军医大学学报》2000年第6期779-780,共2页Journal of the Fourth Military Medical University

摘　　要：目的　探讨小肠移植术后 FK5 0 6血药浓度的影响因素 ,为临床合理化用药提供依据 .方法　观察活体部分小肠移植术后肠内营养等因素对 FK5 0 6血药浓度的影响 .结果　肠内营养物质重量、移植肠造口排出量与 FK5 0 6血药浓度关系密切 .结论　小肠移植术后应常规性的监测 FK5 0 6血药浓度 。AIM To study the effect of internal nutrition on the FK506 blood drug concentration after small intestine transplantation so as to provide a rational basis for the use of drugs clinically. METHODS To observe a patient post transplantation of partial small intestine in vivo to determine the effect of internal nutrition and some other factors on the FK506 blood drug concentration. RESULTS It was found that there was a close correlation between the amount of internal nutrition, the intestinal juice drained on the one hand and the FK506 blood drug concentration on the other. CONCLUSION After small intestine transplantation, the FK506 blood drug concentration should be monitored on a routine basis and its dosage should be adjusted accordingly.

关 键 词：FK506 小肠移植 血药浓度 肠内营养因素 

分 类 号：R656.7[医药卫生—外科学] R979.5[医药卫生—临床医学]