糖代谢异常在多囊卵巢综合征患者促排卵失败中的意义  

Purport of sugar metabolic abnormality for failure of ovulation induction in polycystic ovary syndrome

作　　者：金红[1] 李美芝[2] 赵一鸣[2] 

机构地区：[1]延边妇幼保健院,吉林延吉133002 [2]北京医科大学第三临床医院,北京100083

出　　处：《延边大学医学学报》2000年第2期129-132,共4页Journal of Medical Science Yanbian University

摘　　要：[目的 ]探讨糖代谢异常和胰岛素抵抗在克罗米酚治疗多囊卵巢综合征促排卵失败中的作用 .[方法 ]用克罗米酚促排卵方法治疗 5 7例多囊卵巢综合征不孕患者 .采用氧化酶法进行糖耐量试验 ,采用放射免疫法进行胰岛素释放试验及基础激素的测定 ,分析了多囊卵巢综合征糖代谢异常和胰岛素分泌在促排卵失败中的意义 .[结果 ]5 7例多囊卵巢综合征患者中促排卵失败 2 1例 ,占 36 % ,促排卵失败的相关因素有体重指数、胰岛素抵抗、糖耐量试验后 6 0min ,12 0min的血糖及胰岛素值 ,但糖耐量试验后 12 0min血糖与 12 0min空腹胰岛素比值是多囊卵巢综合征患者促排卵失败的重要危险因素 .[结论 ]糖负荷后的血糖及胰岛素水平是预测克罗米酚治疗多囊卵巢综合征促排卵失败的重要指标 .OBJECTIVE To study the role and significance of sugar metabolic abnormality and insulin resistance (IR) for the failure of ovulation induction with the clomiphene citrate (CC) in patients with polycystic ovary syndrome (PCOS). METHODS The CC was used to treat 57 patients with PCOS induced in fertility. Glycemia and insulin response to the tolerance test with oral glucose load (OGTT) were assessed, and insulin and basal hormone levels were measured by radioimmunol techniques. RESULTS There were 21 cases showed anovulation in 57 patients with PCOS (36%). Failure of ovulation induction was related to body mass index(BMI), IR and 60 min , 120 min post OGTT serum sugar and insulin levels, but the 120 min post OGTT serum sugar and the 120 min/0 min insulin ratio were the important in PCOS patients. CONCLUSION Serum sugar and insulin levels post OGTT are the important markers used to predict failure of ovulation induction by CC in patients with PCOS.

关 键 词：多囊卵巢综合征 排卵 糖代谢异常 

分 类 号：R711.75[医药卫生—妇产科学]