正交试验优选萆清栓的提取工艺  

Extraction Process of BiQing Suppository Optimized with Orthogonal Design

作　　者：梁海宁[1] 沈涛[1] 陈二林[1] 张宏武[1] 王雪岩[1] 

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2012年第12期20-22,共3页Western Journal of Traditional Chinese Medicine

基　　金：兰州市科技发展计划项目(编号2011-ZD-15)

摘　　要：目的:优选萆清栓提取工艺。方法:以水为提取溶剂,药液比、提取时间、提取次数为考察因素,以出膏率及盐酸小檗碱含量为评价指标,采用正交试验优化提取工艺。结果:最佳提取工艺为用10倍量水,1.5 h/次,提取2次。结论:所选择的工艺稳定可行,可用于萆清栓的工业生产。Objective： To optimize extraction process of BiQing suppository. Method： Extraction process was optimized with orthogonal design by taking water as extraction solvent, drug-liquid ratio, extracting time and times as the indexes, the extraction rate and content of berberine hydrochloride as evaluating indicators. Result： the optimal extraction was using ten folds amount of water, reflux extraction twice, once 1.5 hours. Conclusion： The extraction process is stable and could be used to the production of BiQingShuang.

关 键 词：萆清栓 正交试验 提取工艺 盐酸小檗碱 

分 类 号：R284.2[医药卫生—中药学]