慢性乙型肝炎患者中医生存质量量表的临床应用与评价  

Evaluation and clinical application of TCM quality of life scale for chronic hepatitis B

作　　者：王妍[1] 王磊[1] 王俐琼[1] 张玮[1] 王灵台[2] 孙雪华[2] 施美育[3] 黄品贤[3] 姚培芬[4] 

机构地区：[1]上海中医药大学附属龙华医院肝科,上海200032 [2]上海中医药大学附属曙光医院 [3]上海中医药大学 [4]上海市精神卫生中心

出　　处：《中西医结合肝病杂志》2012年第6期330-333,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：上海市卫生局中医药科研基金课题(No.2008L025A)

摘　　要：目的:通过对慢性乙型肝炎(CHB)患者中医生存质量量表(测试版)的临床应用,评价中医生存质量量表的反应度和敏感度。方法:采集90例湿热中阻证和90例肝郁脾虚型CHB患者,随机分治疗组和对照组。运用CHB患者中医生存质量量表(测试版)和慢性肝病问卷(CLDQ)量表进行对比研究。结果:①CHB中医生存质量量表(测试版)与CLDQ量表各维度相关矩阵显示两个量表各自维度间都是呈正相关的。但两个量表之间的两两相关矩阵,显示各维度间不存在相关关系。②CHB患者中医生存质量量表(测试版)评分结果显示:治疗组治疗后的各维度的校标尺度和治疗前比较差异均有统计学意义(P均<0.01)。对照组治疗3个月后的评分仅在情志维度与治疗前比较差异有统计学意义(P均<0.01),其余各维度和总分评分和治疗前比较差异均无统计学差异(P>0.05)。治疗6个月后的评分和治疗前比较差异均有统计学意义(P均<0.01)。结论:①CHB患者中医生存质量量表(测试版)具有自己的特异性,与CLDQ量表有一定的相关性,但相关性不太高。②CHB患者中医生存质量量表(测试版)在对CHB患者的评定中有良好的反应性及敏感度,可以有效地应用于中医药对CHB患者生存质量的疗效评价。Objective： To assess the availability of a TCM quality of life （QOL） scale for CHB （Beta） created by our study team in a randomized controlled clinical trials. Methods： The study included 90 the damp-heat syndrome and 90 liver stagnation and spleen deficiency syndrome patients with CHB. All participants were randomized into two group, treatment group and control group. To compare the sensitivity of QOL scale with chronic liver disease questionnaire （CLDQ） . Results： ①CLDQ and TCM QOL scale for the respective correlation matrix result revealed a positive correlation among all items for both scales. No correlation was found among items for both scales on two two correlation matrix. ②the responsibility of TCM QOL scale for CHB （Beta） ： There were statistically significant differences pre- and post-treatment in calibrated scale of all dimension items from TCM QOL scale in both groups （P all 〈 0. 01 ） . In the control group, statistically significant differences pre- and 3 months post-treatment were only found in emotion suhscale （P all 〈0. 01 ）, while the remaing dimension items and total score similar pre- and post-treatment （P 〉 0. 05） . Also, statistically significant differences pre- and 6 months post-treatment could be found in calibrated scale of all dimension items from TCM QOL scale （ P all 〈 0. 01 ） . Conclusion： ①The created TCM QOL scale is in an identified but relatively loose correlation to CLDQ scale due to its own specificity. ②The created TCM QOL scale （Beta） has a better responsibility and sensitivity in the evaluation of QOL in patients with CHB , which could be an effective utilized in the evaluation system on the efficacy of TCM treatment in QOL of CHB.

关 键 词：肝炎 乙型 慢性 中医生存质量量表 反应度 敏感度 

分 类 号：R259[医药卫生—中西医结合]