非洛地平缓释胶囊的制备及其释药特性研究  

Preparation and Release Properties of Felodipine Sustained-release Capsules

作　　者：吴琼珠[1] 禹道春[1] 戴永健[1] 王芳[1] 

机构地区：[1]第二军医大学南京军医学院,南京210099

出　　处：《中国药科大学学报》2000年第3期177-179,共3页Journal of China Pharmaceutical University

摘　　要：选用羟丙基甲基纤维素为水凝胶型骨架材料 ,乙基纤维素为阻滞剂制备非洛地平缓释胶囊。通过考察其体外释放度 ,评价了该缓释胶囊的处方 ,结果表明该制剂的体外释药行为符合Felodipine was formulated with some excipients to prepare sustained release capsules. The influence of HPMC with different viscosity and EC with different capacity on the drug release in vitro has been studied. The results showed that the release behavior of the capsules followed Higuchi equation.

关 键 词：非洛地平 缓释胶囊 释放度 制备 含量测定 

分 类 号：R944[医药卫生—药剂学]