使用微粉化技术改善头孢呋新酯片的溶出  

Dissolution Improvement of Cefuroxime Axetil Tablets by Using Micronization Technology

作　　者：柯学平 其能 朱颖[1] 

机构地区：[1]中国药科大学药剂教研室,南京210009

出　　处：《中国药科大学学报》2000年第3期188-191,共4页Journal of China Pharmaceutical University

摘　　要：为改善头孢呋新酯片的溶出 ,采用气流粉碎、球磨、重结晶、固态分散技术等多种微粉化技术 ,通过差热分析和 X衍射研究微粉化后头孢呋新酯的晶型特征。结果表明 ,固态分散技术可使该药由晶型转变为无定型 ,从而大大增加其片剂的溶出。In order to improve the dissolution of cefuroxime axetil, we used several types of micronization technology: air jet micronization, ball mill grinding, recrystallization, co precipitate. Crystal properties of cefuroxime axetil after micronization were studied by using DSC and X ray diffraction. The results indicated that co precipitation process might changed the crystal properties and improve the dissolution of cefuroxime axetil tablets. The results were further confirmed by the solubility heat of cefuroxime axetil in various states.

关 键 词：头孢呋新酯 微粉化 气流粉碎 球磨 重结晶 

分 类 号：R96[医药卫生—药理学]