止咳平喘膜剂的药效学研究(Ⅰ)  

Pharmacodynamic Study of Antitussive and Antiasthmatic Film(Ⅰ)

作　　者：李运曼[1] 刘建平[2] 孙宇[1] 凌向平[2] 

机构地区：[1]中国药科大学生理学教研室,南京210009 [2]中国药科大学药剂学教研室,南京210009

出　　处：《中国药科大学学报》2000年第3期218-221,共4页Journal of China Pharmaceutical University

摘　　要：本文对止咳平喘膜剂的药效学进行了初步的研究 ,结果表明 ,该膜剂经皮给药能显著延长蛋清所致豚鼠哮喘和枸橼酸所致豚鼠咳嗽的潜伏期 ;减少枸橼酸所致豚鼠的咳嗽次数 ;对小鼠气管酚红排泌量有明显的促进作用 ;加快小鼠碳粒廓清速率 ;无论是抗原攻击前给药 ,还是攻击后给药均可显著抑制 2 .The pharmacodynamic action of Antitussive and Antiasthmatic Film was studied. The results showed that AAF could significantly prolong the latent time of asthma induced by ovalbumin and that of cough induced by citric acid in guinea pig. It also decreased cough time in guinea pig and promoted secretion of bronchial phenol red in mice. These results suggest that AAF possesses obviously antitussue、antiasthmatic and pectonal action. In addition, AAF could markedly increase the carbon clearance rate of macrophage(Mφ)in mice and inhibit the contact dermatitis caused by dinitrochlorobenzene(DNCB)both before and after antigen challenge.

关 键 词：止咳平喘膜剂 药效学研究 碳粒廓清速率 

分 类 号：R96[医药卫生—药理学]