淫羊藿总黄酮对维A酸诱导大鼠骨质疏松症的防治作用  

Effect of HEF on Osteoporosis Induced by Retinoic Acid in Male Rats

作　　者：季晖[1] 刘康[2] 李绍平[1] 龚小健[1] 

机构地区：[1]中国药科大学药理学教研室,南京210009 [2]中国药科大学中药药理学教研室,南京210009

出　　处：《中国药科大学学报》2000年第3期222-225,共4页Journal of China Pharmaceutical University

基　　金：江苏省科委应用基础基金

摘　　要：以 90 mg/ kg维 A酸结合低钙饲料诱导大鼠形成骨质疏松症 ,模型组大鼠血清碱性磷酸酶 (s-AL P)及热不稳定性碱性磷酸酶 (HIS- s- AL P)显著升高 ,股骨、胫骨骨重 (W)下降 ,骨表观线密度 (W/ L)、表观面密度 (W/ L D )、骨灰重 (Wash)、灰分表观线密度 (Wash/ L )及灰分表观面密度 (Wash/ L D )明显降低。淫羊藿总黄酮75、15 0、30 0 mg/ kg连续给药一个月 ,可降低模型大鼠的 s- AL P与 HIS- s- AL P,提高股骨 Ca、P含量。30 0 mg/ kg剂量组可增加血清钙 (s- Ca)含量 ,提高股骨和胫骨 W/ L、W/ L D以及股骨 W和基质表观面密度 (Wmatrix/ L D)Rat osteoporosis models induced by Retinoic Acid(RA)cooperated with low calcium fodder were used to evaluate the function of HEF. Three doses of HEF(75,150 and 300 mg/kg)were given for one month by oral administration. Compared with model group, HEF could decrease s ALP and HIS s ALP, increase Ca and P content of femur. 300 mg/kg HEF could raise s Ca,increase W/L and W/LD of femur and tibia and femur weight and femur matrix apparent area density( W matrix / LD ).

关 键 词：骨质疏松症 淫羊藿总黄酮 维A酸 防治 

分 类 号：R285[医药卫生—中药学]