桑杏平喘颗粒对大鼠部分生化指标的影响  

Effects of Sangxing Pingchuan Granules on some Biochemical Indices in Bloods of Rats

作　　者：刘晓磊[1] 辛蕊华[1] 郑继方[1] 王贵波[1] 罗超应[1] 谢家声[1] 李锦宇[1] 胡振英[1] 罗永江[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃省中兽药工程技术研究中心,农业部兽用药物创制重点实验室,甘肃兰州730050

出　　处：《中国畜牧兽医》2012年第12期107-112,共6页China Animal Husbandry & Veterinary Medicine

基　　金：“十二五”国家科技支撑计划(2011BAD34B03)

摘　　要：本试验旨在了解桑杏平喘颗粒的安全性,为临床用药提供数据支持。选用健康Wistar大白鼠80只,随机分成4组(1个对照组和3个试验组),每组20只,雌雄各半,对照组灌服生理盐水,试验组分别以桑杏平喘颗粒煎剂,相当于原药材3、15、30 g/kg体重灌胃给药,连续给药30 d,在给药10、20、30 d采血,测定血清中部分生化功能指标。试验结果表明,桑杏平喘颗粒对大鼠肝脏、肾脏、心脏功能的影响较小,是一种适合临床应用的低毒、安全的中药制剂。In order to make clear the safety of Sangxing Pingchuan granules and provide data support for the clinical medication, 80 Wistar rats were randomly divided into four groups（one control group and three treatment groups）,and each group induded 20 rats. The control group was taken normal saline by intragastric administration.The three treatment groups were lavaged with water solutions of Sangxing Pingchuan granules at doses of crude drug 3,15,30 g/（kg·bw）,respectively.The drugs were fed for 30 days continuously,and the blood was collected every nine days for the analysis on some blood biochemical indices.The results showed that Sangxing Pingchuan granules affected less on liver,kidney and heart functions of the rats.So it was a low toxic and safe traditional Chinese medicine preparation which was suitable for clinical application.

关 键 词：桑杏平喘颗粒 大鼠 生化指标 安全性评价 猪支原体肺炎 

分 类 号：S853.75[农业科学—临床兽医学]