阿巴卡韦为基础的方案在HIV/AIDS病人治疗中的应用  

Review of abacavir-based regimens in HIV/AIDS treatment

作　　者：肖江[1] 赵红心[1] 

机构地区：[1]首都医科大学附属北京地坛医院感染中心,北京100015

出　　处：《中国艾滋病性病》2012年第12期891-895,共5页Chinese Journal of Aids & STD

基　　金：北京自然科学基金"瘦素;脂联素基因多态性与艾滋病并发脂肪肝相关性分析"(7112065);十二五重大专项"北京市朝阳区艾滋病和病毒性肝炎等重大传染病综合防治示范区建设研究(2012ZX10004-904)~~

摘　　要：目的阿巴卡韦(Abacavir,ABC)是一种鸟嘌呤核苷类似物,ABC/拉米夫定(Lamivudine,3TC)在艾滋病病毒(Human immunodeficiency virus,HIV)感染者中具有良好的安全性、耐受性和抗病毒能力。ABC/3TC不通过肝脏细胞色素P450代谢,药物之间的相互作用少。HLA-B5701基因在中国艾滋病病人中比例极低,发生ABC超敏反应的比例亦极低,但对可能发生的过敏性症状、体征仍需注意。服用以ABC/3TC为骨干的核苷类抗病毒药物,较同类抗病毒药物出现心血管事件、心梗、肾损害和骨骼损害的发生率较低,对病人的长期治疗有益处。但仍需警惕。目前虽然有研究显示,在高病毒载量HIV RNA>105拷贝/mL时,疗效可能不如同类抗病毒药物,但是最新的CANOC研究证实,ABC/3TC和替诺福韦/恩曲他滨(Tenofovir,TDF/Emtricitabine,FTC)相比较,对初治病人抗病毒治疗疗效没有差别,不管基线的病毒载量水平如何。Objective Abacavir（ABC） is a guanosine analogue,and ABC/3TC（Lamivudine） as a key highly active antiretroviral therapy（HAART） regimen for human immunodeficiency virus（HIV） positive patients has been found with a good safety, tolerability and antiviral capabilities. ABC/3TC is not metabolized by the hepatic cytochrome P450, and is found having less interactive with other drugs. The percentage of HLA-B5701 gene in Chinese patients is very low. The proportion of ABC hypersensitivity, myocardial infarction, bone mineral density and fractures and renal dysfunctions are also very low, but still need to be alert to allergic and cardiac signs and symptoms that may occur. CANOC identified no differences in efficacy between ABC/3TC and TDF/FTC regardless of the baseline viral load in the initial therapy of ART-naive patients.

关 键 词：阿巴卡韦 HIV/AIDS病人 抗病毒治疗 应用 

分 类 号：R512.91[医药卫生—内科学]