毒死蜱中间体3,5,6-三氯吡啶-2-酚的合成  

Synthesis of 3,5,6-trichloropyridin-2-ol for chlorprifos intermediate

作　　者：熊华亮[1] 蒋玉仁[1] 

机构地区：[1]中南大学化学化工学院,湖南长沙410013

出　　处：《江西化工》2012年第2期51-53,共3页Jiangxi Chemical Industry

基　　金：国家自然科学基金项目人(20876180)

摘　　要：本文报道了以硝基苯为溶剂,三氯乙酰氯和丙烯腈为主要原料在氯化亚铜和铜粉复合催化剂催化下合成三氯吡啶酚的方法。实验研究结果表明,当反应物投料比n[CCl3COCl]:n[CH2CHCN]为1:1.3,加成环化反应温度为135℃、反应时间为11h,芳香化反应在55℃的温度条件下反应4h时,最高反应收率可达到71.3%,高于目前国内报道的先进水平。The article introduced synthetic methods for 3,5,6-trichloropyridin–2-ol.Using nitrobenzene as solvent,3,5,6-trichloropyridin-2-ol was synthesized from trichloroacetyl chloride and acrylonitrile on the Cuprous chloride and copper composite catalysts.The results showd that when mole ratio of trichloroacetyl chloride to acrylonitrile was 1：1.3,addition and cyclization temperature was 135℃、reaction time was 11h,aromatization temperature was 55℃ and time was 4h,the total yield could reach 71.3%,which is superior to the Reports of the domestic advanced level.

关 键 词：三氯乙酰氯 丙烯腈 合成 3 5 6-三氯吡啶-2-酚 

分 类 号：TQ450.4[化学工程—农药化工]