氯硝柳胺改性灭尾蚴药物小试生产工艺的研究  

The production engineering research of an emergency anti-cercaria drug

作　　者：李波[1] 刘红波[1] 范小林[1] 

机构地区：[1]赣南师范学院有机药物化学重点实验室,341000

出　　处：《江西化工》2012年第2期118-122,共5页Jiangxi Chemical Industry

摘　　要：对氯硝柳胺进行改性,在其羟基上接上聚乙二醇基可以大大增加氯硝柳胺在水面的表面扩散性,更有利于杀灭血吸虫尾蚴。本文主要研究了聚乙二醇基氯硝柳胺衍生物的合成小试工艺,并对小试工艺的步骤、反应过程的控制、原料的回收利用等进行了简化和优化。To modificate Niclosamide,We connect a polyethylene glycol to niclosamide to enhance its expansionary on the surface of water.In this work,the production engineering of the derivate of niclosamide was derivatived composite test process,and to test the technology and reaction process steps,the control of raw materials such as the recycling of simplified and optimization.

关 键 词：氯硝柳胺 聚乙二醇 改性 尾蚴 优化 

分 类 号：R184[医药卫生—流行病学]