睡眠呼吸暂停综合征及鼾症患者事件相关电位的研究  

Abnormal P3 latency in obstructive sleep apnea syndrome, but normal in snore

作　　者：彭斌[1] 李舜伟[1] 黄席珍[2] 汤晓芙[1] 吴全有[2] 罗英[2] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院神经科,100730 [2]中国医学科学院中国协和医科大学北京协和医院,100730

出　　处：《中华医学杂志》2000年第6期429-431,共3页National Medical Journal of China

摘　　要：目的　研究睡眠呼吸暂停及鼾症患者事件相关电位 (P3)的情况 ,探讨可能的机制。方法　入组受试者分为睡眠呼吸暂停患者组 2 1例、鼾症组 2 1例及正常对照组 2 1例 ,均进行睡眠多导仪、听觉诱发事件相关电位 (P3)、临床记忆量表检查及神经系统查体。结果采用GLM程序分析。结果　睡眠呼吸暂停患者组记忆商 (MQ) 90± 12 ,P3潜伏期Fz记录点 :36 3ms± 2 3ms ,Cz记录点 :36 9ms± 2 8ms;鼾症组MQ :10 1± 17,P3潜伏期 :Fz记录点 :337ms± 31ms ,Cz记录点 :340ms± 32ms ;正常对照组MQ :114± 12 ,P3潜伏期 :Fz记录点 :341ms± 2 9ms ,Cz记录点 338ms± 30ms。睡眠呼吸暂停患者组与鼾症组、正常对照组的P3潜伏期和记忆商比较差异有显著意义 (P <0 0 5 )。鼾症患者记忆商较正常对照组降低。结论　睡眠呼吸暂停患者有认知功能损害。鼾症患者记忆功能减退。Objectives To evaluate the P3 wave (latency, amplitude) in snorers and patients with obstructive sleep apnea syndrome (OSAS) and investigate the possible mechanism. Methods Three groups, OSAS patient group ( n =21), snorer group ( n =21) and control group ( n =21), were administered polysomnography (PSG), auditory evoked event related potential (P3) and clinic memory test. The results were analyzed using GLM analysis and Post Hoc test. Results The auditory P3 latency in OSAS group was 363 ms±22 ms (Fz), 369 ms±28 ms (Cz), in snorer group 336 ms±31 ms (Fz), 340 ms±32 ms (Cz), and in control group 341 ms±29 ms (Fz), 338 ms±30 ms (Cz). There were significant differences between OSAS group and snorer group, as well as control group ( P <0.05). No significant difference was seen between snorer group and control group. Memory quotient (MQ) was reduced in snoren group as compared with control group. Conclusion Abnormal auditory P3 latency indicates the cognitive dysfunction in OSAS patients . Nocturnal hypoxaemia may play an important role.

关 键 词：睡眠呼吸暂停综合征 鼾症 事件相关电位 

分 类 号：R56[医药卫生—呼吸系统]