中国学龄儿童瘦素受体基因SNP rs1137101多态分布与肥胖相关性研究  

RELATIONSHIP BETWEEN SNP rs1137101 VARIATION IN LEPTIN RECEPTOR GENE AND OBESITY IN CHINESE ELEMENTARY SCHOOL CHILDREN

作　　者：薛琨[1,2] 郭红卫[1,2] 万文涛[1,2] 骆璇[1,2] 王文娴[1,2] 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生教研室,上海200032 [2]教育部公共卫生安全重点实验室

出　　处：《营养学报》2012年第6期536-539,共4页Acta Nutrimenta Sinica

基　　金："十一五"国家科技支撑计划重点项目(No.2008BAI58B05)

摘　　要：目的探讨瘦素受体基因SNP rs1137101多态分布与儿童肥胖之间的关联。方法对1682名上海某区小学学龄儿童进行身高、体重、腰围测量,及瘦素受体基因SNP rs1137101多态位点基因型分析,通过非条件Logistic回归、卡方检验等方法分析该基因位点多态分布与体重指数(BMI)、腰围身高比(WHtR)等肥胖相关参数之间的关系。结果该人群LEPR基因SNP rs1137101多态位点基因型AA、AG及GG频率分别为0.012、0.224、0.764,等位基因A和G的分布频率分别为0.14和0.86,符合Hardy Weinberg遗传平衡定律(∑X2=1.301,p>0.05);调整性别、年龄、学校所在地区后,AA/AG组和GG组中超重率分别为13.1%和9.1%,其OR值为1.43(95%CI:0.97-2.10,p=0.074),BMI高组和低组中AA/AG基因型携带者比例分别为26.3%和21.1%,其OR值为1.30(95%CI:1.01-1.68)。结论 LEPR基因SNP rs1137101多态位点携带A等位基因与中国学龄儿童超重及高BMI相关,是该人群肥胖的易感因素之一。[营养学报,2012,34(6):536-539]Objective To investigate the relationship between SNP rs1137101 polymorphism in the LEPR gene and obesity in Chinese children.Method One thousand,six hundred and eighty-two elementary school children in Shanghai,China were selected.Their heights,weights,waist circumferences were measured and bloods samples were collected for DNA genotyping.The associations between SNP rs1137101 and BMI,waist height ratio（WHtR）,obesity（OB） prevalence were analyzed by Logistic regression or Chi-square test.Results For LEPR SNP rs1137101,the frequencies of genotypes AA,AG,GG and alleles A,G were 0.012,0.224,0.764 and 0.14,0.86 respectively,in agreement with those expected under Hardy –Weinberg equilibrium（∑X2 =1.301,P0.05）.After additional adjusting age,sex and area of school,overweight（OW） prevalence in AA/AG group was higher than that in GG group（13.1% vs.9.1%,OR=1.43,95%CI： 0.97-2.10,P=0.074） and there were more AA/AG carriers in BMIP50 group than in BMIP50 group（26.3% vs.21.1%,OR=1.30,95%CI： 1.01-1.68）.Conclusion LEPR SNP rs1137101 polymorphism may be a relavent obesity marker in Chinese children,with alleles A at the sites associated with overweight or higher BMI.[ACTA NUTRIMENTA SINICA,2012,34（6）：536-539]

关 键 词：儿童肥胖 瘦素受体 基因多态性 BMI 腰围身高比 

分 类 号：R725.8[医药卫生—儿科]