冻疮发生与Ⅰ型超敏反应体质之间的关系调查  

An Investigation on the Relationship between Chilblain and the Constitution of Type Ⅰ Hypersensitivity

作　　者：黄瀚 李仕剑 

机构地区：[1]湖南食品药品职业学院专业建设科,长沙市410116

出　　处：《中华全科医学》2013年第1期116-117,共2页Chinese Journal of General Practice

摘　　要：目的了解冻疮的发生与Ⅰ型超敏反应体质之间的关系,探讨组胺在冻疮发生中的作用。方法 2009～2011年,以部分师生为调查对象,采用现场问卷法调查,并采取有效的质量控制措施避免人为因素对调查结果的干扰。结果 417例受访师生中,各类Ⅰ型超敏反应病史者103例,其冻疮患病率91.26%。未有过Ⅰ型超敏反应病史者中,冻疮病史者143例,患病率45.54%。两者患病率比较,差异有统计学意义(P<0.05);受访师生中皮肤型Ⅰ型超敏反应病史者94例(含其它类型Ⅰ型超敏反应合并皮肤型Ⅰ型超敏反应者),冻疮患病率93.61%,其它类型Ⅰ型超敏反应病史者9例,冻疮患病率66.67%。两者患病率比较差异有统计学意义(P<0.01)。结论Ⅰ型超敏反应体质与冻疮发生有密切的关系;组胺对冻疮的发生可能有触发作用。Objective To investigate the relationship between chilblain and the constitution of type I hypersensitivity, and study the role of Histamine in chilblain. Methods A part of teachers and students of our college were used as investigation ob- ject from 2009 to 2011. With site paper investigation method, and avoiding interference of human factor by effective quality control measures. Results Among the teachers and students surveyed,there were 103 cases who had history of various type I hypersen- sitivity. The prevalence of chilblain was 91.26%. The history of chilblain were 143 cases who had no history of I hypersensitivi- ty ,The prevalence of chilblain was 45.54%. It showed greater difference between two groups（ P 〈 0.05 ）. There were 94 cases who had the skin type I hypersensitivity（ including the other types I hypersensitivity complicated with the skin type I hypersensi- tivity）, the prevalence of chilblain was 93.61%, and there were 9 cases who had the other type I hypersensitivity, the prevalence of chilblain was 66.67%, it showed greater difference between two groups also （ P 〈 0.01 ）. Conclusion The chilblain was close- ly correlated with the constitution of type I hypersensitivity and Histamin would trigger chilblain.

关 键 词：I型超敏反应 冻疮 体质 调查 组胺 

分 类 号：R758.11[医药卫生—皮肤病学与性病学]