氨基葡萄糖联合布洛芬与单用布洛芬治疗髋关节骨关节炎前瞻性随机对照临床研究  

Combination of Glucosamine Hydrochloride and Non-Steroidal Anti-Inflammatory Drugs versus Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Hip Osteoarthritis: A Prospective,Randomized and Controlled Clinical Study

作　　者：曾伟南[1] 周宗科[1] 李海[1] 沈彬[1] 杨静[1] 康鹏德[1] 裴福兴[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《华西医学》2012年第12期1805-1808,共4页West China Medical Journal

摘　　要：目的探讨氨基葡萄糖联合布洛芬治疗髋关节骨关节炎的临床疗效。方法 2011年9月-2012年1月采用前瞻性随机对照临床试验,将198例轻、中度髋关节骨关节炎患者随机分入试验组及对照组。试验组采用氨基葡萄糖(750 mg,2次/d口服,疗程1个月)联合布洛芬(0.3 g,2次/d口服,疗程2周),对照组则单用布洛芬(0.3 g,2次/d口服,疗程2周);分别于服药后0、2、4、8及12周时采用加拿大西安大略和麦克玛斯特大学骨关节炎指数(WOMAC)进行疗效评价。并对恶心、呕吐、皮疹等药物不良反应进行观察。结果试验组与对照组WOMAC各项评分从第2周开始较0周明显下降,而两组患者间在0周及2周时WOMAC评分无统计学差异:0周总评分(45.3、45.0分,P=0.225),2周总评分(37.3、37.6分,P=0.329)。但对照组WOMAC各项评分从第4周开始逐渐呈现上升趋势,而试验组到第12周仍呈现持续性下降趋势。总不良反应发生率为7.0%,其中试验组总不良反应发生率为9.5%,但不良反应轻微,未予特殊处理而自行消失。结论氨基葡萄糖联合布洛芬可有效缓解早、中期髋关节骨关节炎各项临床症状,疗效确切,不良反应较少,且停药后仍持续表现出治疗效果。而单用布洛芬可短期缓解骨关节炎症,但停药后症状逐渐复现。Objective To discuss the clinical efficacy of glucosamine combined with non-steroidal anti-inflammatory drugs（NSAID） on the treatment of hip osteoarthritis.Methods From September 2011 to January 2012,198 patients with mild to moderate hip osteoarthritis were selected,and were divided into trial group and control group randomly.The patients in the trial group was medicated with glucosamine（750 mg,twice per day for 1 mouth） and ibuprofen（0.3 g,twice per day for 2 weeks）,and the ones in the control group were with ibuprofen（0.3 g,twice per day for 2 weeks） only.Then the clinical results were evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC） on week 0,2,4,8 and 12.And the adverse drug reaction were observe.Results The WOMAC score decreased from week 2 when compare to week 0 after treatment in both groups.But there was no significant difference between the trial and control group： week 0 WOMAC score（45.3 and 45.0,P=0.225）,and week 2 WOMAC score（37.3 and 37.6,P=0.329）.But the WOMAC score in control group began to ascend form week 4,however the WOMAC score in trial group decreased persistently.Total adverse reaction ratio was 7.0% in both groups while adverse reaction ratio was 9.5% in trial group.Conclusions The clinical symptoms of mild to moderate hip osteoarthritis can be effectively relieved by glucosamine combined with ibuprofen,and shows therapeutic effect after drug withdrawal.Ibuprofen has short-term improvement for the clinical symptoms of hip osteoarthritis,but the symptoms reoccur after drug withdrawal.

关 键 词：氨基葡萄糖 布洛芬 骨关节炎 髋 

分 类 号：R684[医药卫生—骨科学]