盐酸氨基葡萄糖联合尼美舒利治疗腰椎小关节骨关节炎的近期疗效  

Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis

作　　者：丁玉辉[1] 李森[2] 

机构地区：[1]泸州医学院附属医院麻醉科,四川泸州6460001 [2]泸州医学院附属医院脊柱外科,四川泸州6460001

出　　处：《华西医学》2012年第12期1814-1817,共4页West China Medical Journal

摘　　要：目的观察盐酸氨基葡萄糖治疗腰椎小关节骨关节炎的临床疗效。方法 2010年9月-2012年5月门诊就诊的160例腰椎小关节骨关节炎患者随机分为两组进行治疗,对照组80例,口服非甾体抗炎药物尼美舒利;试验组80例,在服用尼美舒利的基础上加服盐酸氨基葡萄糖,治疗周期为2周。对两组患者治疗前及治疗后1、2周后日常生活能力、视觉疼痛模拟、心理测评(采用症状自评量表检测)3项指标进行检测,比较两组的临床疗效,并对患者进行3个月随访。结果两组患者各指标检测结果显示,治疗后较治疗前均明显改善,试验组明显优于对照组;总有效率试验组为97.3%,对照组为86.1%,试验组明显优于对照组,组间比较差异有统计学意义(P<0.05)。结论盐酸氨基葡萄糖联合尼美舒利治疗腰椎小关节骨关节炎具有较好的临床疗效。Objective To observe the clinical efficacy of glucosamine hydrochloride combined with nimesulide in the treatment for the patients with lumbar facet joint osteoarthritis.Methods？A total of 160 patients with lumbar facet joint osteoarthritis treated between September 2010 and May 2012 were randomly divided into the control group and the experimental group with 80 in each.Nimesulide was used for patients in the control group,while for the other 80 patients in the experimental group,glucosamine hydrochloride combined with nimesulide was used.For patients in both groups,treatment was lasted for two weeks.We detected the activities of daily living（ADL） and visual analogue pain（VAS）,and carried out the psychological evaluation for the patients.Clinical efficacy was compared between the two groups.At the same time,we followed up the patients for 3 months.Results？The results showed that the symptoms of the patients in both groups were significantly alleviated.The total efficiency was 97.26% in the experimental group and 86.11% in the control group.The clinical efficacy was more significant in the experimental group than in the control group（P0.05）.Conclusion？It is effective to use glucosamine hydrochloride combined with nimesulide to treat lumbar facet joint osteoarthritis.

关 键 词：盐酸氨基葡萄糖 骨关节炎 腰椎小关节 临床疗效 

分 类 号：R684.3[医药卫生—骨科学]