Energy power in mountains:difference in metabolism pattern results in different adaption traits in Tibetans  

作　　者：Zhen-zhong BAI Guo-en JIN Tana WU-REN Qin GA Ri-li GE 

机构地区：[1]The Research Center for High Altitude Medicine,Medical School,Qinghai University

出　　处：《中国应用生理学杂志》2012年第6期488-493,共6页Chinese Journal of Applied Physiology

基　　金：supported by the"973"National Basic Research Program(2012CB51820500);National Natural Science Foundation of China(NSFC,31160219,81160243,31160232,81160012);Qinghai University Medical School Youth and Middle Scientist Cultura Project in 2012

摘　　要：Energy metabolism plays an important role in life survival for species living in high altitude hypoxia condition.Air-breathing organisms require oxygen to create energy.Tibetans are the well-adapted highlanders in Qinghai-Tibetan Plateau.It was thought that different metabolic approaches could lead to different adaptation traits to high altitude hypoxia.Recently identified hypoxia inducible factors pathway regulators,endothelial PAS domain protein1(EPAS1)/HIF-2α and PPARA,were involved in decreasing hemoglobin concentrations in Tibetans.Because EPAS1 and PPARA also modulated the energy metabolism during hypoxia,we hypothesized that positive selected EPAS1 and PPARA genes were also involved in unique energy metabolisms in Tibetans.In this brief review,we take a look into genetic determinations to energy metabolisms for hypoxia adaptations traits in Tibetans and mal-adaptive conditions such as high altitude diseases.Energy metabolism plays an important role in life survival for species living in high altitude hypoxia condition.Air-breathing organisms require oxygen to create energy.Tibetans are the well-adapted highlanders in Qinghai-Tibetan Plateau.It was thought that different metabolic approaches could lead to different adaptation traits to high altitude hypoxia.Recently identified hypoxia inducible factors pathway regulators,endothelial PAS domain protein1（EPAS1）/HIF-2α and PPARA,were involved in decreasing hemoglobin concentrations in Tibetans.Because EPAS1 and PPARA also modulated the energy metabolism during hypoxia,we hypothesized that positive selected EPAS1 and PPARA genes were also involved in unique energy metabolisms in Tibetans.In this brief review,we take a look into genetic determinations to energy metabolisms for hypoxia adaptations traits in Tibetans and mal-adaptive conditions such as high altitude diseases.

关 键 词：藏族人 代谢模式 性状 缺氧诱导因子 血红蛋白浓度 能量代谢 发电 能源 

分 类 号：Q959.802[生物学—动物学] V271[航空宇航科学与技术—飞行器设计]