Beneficial effects of intermittent hypobaric hypoxia on the body  

作　　者：Yi ZHANG Zhao-nian ZHOU 

机构地区：[1]Department of Physiology,Hebei Medical University,and Hebei Key Laboratory of Medical Biotechnology [2]Laboratory of Hypoxic Cardiovascular Physiology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences

出　　处：《中国应用生理学杂志》2012年第6期504-509,共6页Chinese Journal of Applied Physiology

基　　金：supported by National Basic Research Program of China(2006CB504100,2012CB518200);National Natural Science Foundation(30393130,31071002);Science and Technology committee of Shanghai Municipality(02JC14038);Science and technology program of Hebei province(09276115)

摘　　要：Myocardial ischemia and reperfusion(I/R) is a common problem in clinic and there is no satisfactory method for prevention or treatment of I/R injury so far.Chronic intermittent hypobaric hypoxia(CIHH),similar to the concept of ischemia preconditioning(IPC)or altitude hypoxia adaptation(AHA),has been recognized to confer a protective effect on heart against I/R injury with a longer protective effect than IPC and a less adverse effect than AHA.It has been proved that CIHH increases myocardial tolerance to ischemia or hypoxia,reserving cardiac function and preventing arrhythmia during I/R.Multiple mechanisms or pathway underlying the cardiac protection of CIHH have been proposed,such as induction of heatshock protein,enhancement of myocardial antioxidation capacity,increase of coronary flow and myocardial capillary angiogenesis,activation of adenosine triphosphate(ATP)-sensitive potassium channels,inhibition of mitochondrial permeability transition pores,and activation of protein kinase C(PKC) and induced nitric oxide synthase(iNOS).In addition,CIHH has been found having many beneficial effects on the body,such as promotion of health,increase of oxygen utilization,and prevention or treatment for some diseases.The beneficial effects of CIHH and potential mechanisms are reviewed mainly based on the researches performed by our group.Myocardial ischemia and reperfusion（I/R） is a common problem in clinic and there is no satisfactory method for prevention or treatment of I/R injury so far.Chronic intermittent hypobaric hypoxia（CIHH）,similar to the concept of ischemia preconditioning（IPC）or altitude hypoxia adaptation（AHA）,has been recognized to confer a protective effect on heart against I/R injury with a longer protective effect than IPC and a less adverse effect than AHA.It has been proved that CIHH increases myocardial tolerance to ischemia or hypoxia,reserving cardiac function and preventing arrhythmia during I/R.Multiple mechanisms or pathway underlying the cardiac protection of CIHH have been proposed,such as induction of heatshock protein,enhancement of myocardial antioxidation capacity,increase of coronary flow and myocardial capillary angiogenesis,activation of adenosine triphosphate（ATP）-sensitive potassium channels,inhibition of mitochondrial permeability transition pores,and activation of protein kinase C（PKC） and induced nitric oxide synthase（iNOS）.In addition,CIHH has been found having many beneficial effects on the body,such as promotion of health,increase of oxygen utilization,and prevention or treatment for some diseases.The beneficial effects of CIHH and potential mechanisms are reviewed mainly based on the researches performed by our group.

关 键 词：低氧适应 间歇性 有益作用 诱导型一氧化氮合酶 心肌缺血再灌注 低压 保护作用 心脏功能 

分 类 号：Q959.836[生物学—动物学] S5[农业科学—作物学]