Effect of high mobility group box-1 protein on immune cells and its regulatory mechanism  

作　　者：Ying-yi LUAN Feng-hua YAO Qing-hong ZHANG Xiao-mei ZHU Ning DONG Yong-ming YAO 

机构地区：[1]Burns Institute,First Hospital Affiliated to the Chinese PLA General Hospital

出　　处：《中国应用生理学杂志》2012年第6期548-554,共7页Chinese Journal of Applied Physiology

基　　金：supported,in part,by grants from the National Natural Science Foundation(81130035,30971192,81071545,81272090,81121004);the National Basic Research Program of China(2012CB518102)

摘　　要：High mobility group box-1 protein(HMGB1),which is a nuclear protein,participates in chromatin architecture and transcriptional regulation.When released from cells,HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to injury.In the initial stage of injury,there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens,but this pro-inflammatory period is transient,and it is followed by a prolonged period of immune suppression.At present,several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity,which may enhance the production of early proinflammatory mediators,and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated immunity.The biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation,however,this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.High mobility group box-1 protein（HMGB1）,which is a nuclear protein,participates in chromatin architecture and transcriptional regulation.When released from cells,HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to injury.In the initial stage of injury,there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens,but this pro-inflammatory period is transient,and it is followed by a prolonged period of immune suppression.At present,several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity,which may enhance the production of early proinflammatory mediators,and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated immunity.The biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation,however,this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.

关 键 词：免疫细胞 调控机制 核蛋白 迁移率 HMGB1 炎症介质 基因转录调控 免疫反应 

分 类 号：S852.4[农业科学—基础兽医学] S852.659.5[农业科学—兽医学]