胃肠道营养物质代谢与胰高血糖素样肽-1水平改变  

Regulation of Glucagon-Like Peptide-1 Level by Metabolism of Gastrointestinal Nutrients

作　　者：冯潇[1] 王勇[1] 

机构地区：[1]中国医科大学附属盛京医院胆道,疝及减肥外科,辽宁沈阳110004

出　　处：《中国普外基础与临床杂志》2012年第12期1286-1290,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金(项目编号:81000158);辽宁省教育厅自然科学基金(项目编号:L2010591)~~

摘　　要：目的介绍胃肠道营养物质代谢与胰高血糖素样态-1(GLP-1)水平关系的研究现状。方法收集近年来国内、外有关胃肠道营养物质代谢与GLP-1水平关系的文献并作综述。结果 GLP-1影响胰岛素的分泌及其敏感性,在糖代谢恢复中发挥主导作用。胃肠道营养物质代谢影响GLP-1水平。胃转流术(GBP)治疗2型糖尿病(T2DM)可能主要与其影响GLP-1水平有关。结论胃肠道营养物质代谢调控GLP-1水平在GBP治疗T2DM中起了重要作用,相应的深入研究将为T2DM的治疗开辟一个新的领域。Objectives To summarize the regulation of glucagon-like peptide-1 （GLP-1） level by metabolism of gastrointestinal nutrients. Methods Domestic and international publications online involving regulation of GLP-1 level by metabolism of gastrointestinal nutrients in recent years were collected and reviewed. Results GLP-1 influenced insulin secretion and sensitivity, and played a leading role in recovery of glucose metabolism. Metabolism of gastrointestinal nutrients regulated GLP-1 level. Studies had shown that GLP-1 was a candidate mediator of the effects of gastric bypass （GBP） for type 2 diabetes mellitus （T2DM）. Conclusions It plays an important role in anti-T2DM effects of GBP that metabolism of gastrointestinal nutrients regulated GLP-1 level. The corresponding studies can provide a novel clinical field to treat T2DM.

关 键 词：2型糖尿病 胃转流术 胃肠道 营养物质 胰高血糖素样肽-1 

分 类 号：R656.61[医药卫生—外科学] R587.1[医药卫生—临床医学]