TGF-β1及其受体与肝癌转移复发关系的研究进展  

Role of TGF-β1 and its receptors in malignant progression of hepatocellular carcinoma

作　　者：程林[1] 向广阳[1] 陈德[1] 

机构地区：[1]广州医学院第二附属医院肝胆外科,广东省广州市510260

出　　处：《世界华人消化杂志》2012年第33期3231-3236,共6页World Chinese Journal of Digestology

基　　金：广东省科技计划基金资助项目;No.2010B060900088~~

摘　　要：转化生长因子1(transforming growth factor-beta1,TGF-β1)是一种具有多向生物学效应的多肽类细胞调节因子,其膜受体Ⅰ型转化生长因子-受体(transforming growth factor-beta typeⅠreceptor,TGFBRⅠ)、TGFBRⅡ以及TGFBRⅢ在TGF-β1的跨膜信号转导过程中发挥极其重要的作用.TGF-β1及其受体种类较多、功能较为复杂,其表达异常可导致多种疾病,尤其在肿瘤性疾病中更为常见.肝癌(hepatocellular carcinoma,HCC)是一种恶性程度较高的实体性肿瘤,高转移和易复发的特性是导致患者病死率高的重要原因.近期研究表明TGF-β1信号通路功能紊乱与HCC的发生发展密切相关,HCC微环境中TGF-β1及其受体表达水平的改变可通过多种途径促进HCC的恶性进展.本文将对TGF-β1及其受体的结构功能以及在肝癌复发转移方面的研究进展进行综述.Transforming growth factor-beta I （TGF-β1） is a cytokine which exerts a wide range of biological activities by initiating downstream signaling. As transmembrane receptors, TGFBR I, TGFBR II and TGFBRIII have been shown to play an important role in mediating TGF-β1 signal transduction. Owing to roles in promoting cell growth and development, alterations in TGF-β1 and its receptors may result in many diseases, especially tumors. Hepatocellular carcinoma （HCC） is a common malignant solid tumor with high risk of metastasis and recurrence and is associated with a high fatality. Recent studies point to a close relationship between hepatocel- lular carcinoma and the dysregulation of TGF-β1 signaling pathway. The changes in the levels of TGF-β1 and its receptors in tumor microenvi- ronment may facilitate the invasive potential of

关 键 词：转化生长因子Β1 转化生长因子Β受体 肝癌 转移 复发 

分 类 号：R735.7[医药卫生—肿瘤]