原发性系统性淀粉样变1例  

A Case of Primary Systemic Amyloidosis

作　　者：牛牧[1,2] 李其林[1,2] 何丹华[1,2] 黄永华[1,2] 陆小娟[1,2] 

机构地区：[1]暨南大学附属第四医院皮肤科 [2]广州市红十字会医院皮肤科,广东广州510220

出　　处：《皮肤性病诊疗学杂志》2012年第6期359-361,共3页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：患者,男,58岁,四肢伸侧、臀部皮疹伴瘙痒20余年。患者以四肢皮疹为首发症状,查体舌肿大,质地较硬,心肺腹未见明显异常,全身浅表淋巴结未触及。辅助检查:尿常规提示大量红细胞及中量蛋白尿,血肌酐及尿素水平升高,左侧胸膜增厚,提示存在其他系统受累。皮肤病理示:角化过度,鳞状上皮轻度增生,真皮内见均质嗜酸性的物质沉积,刚果红染色阳性。诊断为原发性系统性淀粉样变病。A 58-year-old man suffered from itchy eruptions on the extensive surface of extremi- ties and buttocks for 20 years. Skin lesions was the most prominent and primary manifestation. Physical examination showed glossauxesis with hard texture, no significant abnormality of cardiopulmonary and abdominal, and no swelling of general superficial lymph nodes. Accessory examination found a large number of red blood cells in urine and moderate proteinuria, an increase in creatinine and BUN as well as left side pleural thickening , which suggested the involvement of other systems. Skin biopsy showed mild hyperplasia of squamous cells and hyperkeratosis. The homogeneous eosinophilic material was found to deposit at the dermis of which congo red staining was positive. The diagnosis of primary systemic amvloidosis was made.

关 键 词：淀粉样变 系统性 原发性 肾淀粉样变 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]