调节性T细胞在过敏性鼻炎及抗原特异性免疫治疗中的作用  

Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy

作　　者：娄玮[1,2] 王成硕[1,2] 张罗[1,2] 

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科 [2]北京市耳鼻咽喉科研究所耳鼻咽喉头颈科学重点实验室,北京100730

出　　处：《首都医科大学学报》2012年第6期729-734,共6页Journal of Capital Medical University

基　　金：国家杰出青年科学基金(81025007);国家自然科学基金(81000405;30973282);北京市自然科学基金(7102030)~~

摘　　要：免疫系统是一个高速运转的复杂网络系统,当机体遇到环境中的抗原、细菌、病毒等异物侵袭,它会及时做出相应的免疫反应。过敏性疾病的发生是一个复杂的免疫过程,目前对其机制的研究还处于探索之中,近些年,随着Treg细胞的出现及对其认识的不断加深,人们渐渐意识到"免疫耐受"的形成对维持机体的免疫环境的稳定发挥着重要作用。而Treg细胞在诱导和维持免疫耐受中的核心作用已得到肯定,本文将会对Treg细胞在过敏性鼻炎及抗原特异性免疫治疗中的作用加以阐述。The immune system is a complex network, and it promptly produces the appropriate immune response to invasion of antigen, bacteria, viruses, etc. The mechanism of the allergic disease is still unclear. However, in recent years, with the understanding of regulatory T cells（ Treg cells）, people realize that ＂immune tolerance＂ plays an important role in the stability of the environment to maintain the body＇ s immunity. Treg cells play an important role in the induction and maintenance of immune tolerance. This review highlights current knowledge of the role of Treg cells in the mechanism of allergic rhinitis and the antigen-specific immunotherapy.

关 键 词：调节性T细胞 FOXP3 特异性免疫治疗 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]