吡咯烷二硫甲酸盐对大鼠心肌梗死后心、肾肿瘤坏死因子α表达的影响  

Influence of pyrrolide dithiocarbamate on tumor necrosis factor α expression of the rat heart and kidney tissues after myocardial infraction

作　　者：石静[1] 白慧健[2] 梁勇刚[3] 

机构地区：[1]山西医科大学汾阳学院 解剖学教研室 [2]山西医科大学汾阳学院 组织学与胚胎学教研室 [3]山西医科大学汾阳学院 形态Ⅰ实验室,汾阳032200

出　　处：《解剖学杂志》2012年第6期733-736,共4页Chinese Journal of Anatomy

摘　　要：目的：研究核转录因子-κB（NF-κB）抑制剂吡咯烷二硫甲酸盐（PDTC）对心肌梗死后心力衰竭大鼠心、肾肿瘤坏死因子-α（TNF-α）蛋白表达的影响及意义。方法：通过结扎左冠状动脉前降支4周建立大鼠心肌梗死后心力衰竭模型。采用免疫组织化学观察PDTC干预后心衰大鼠心、肾组织TNF-α蛋白表达变化。结果：与假手术PDTC干预组相比，PDTC干预心衰大鼠后，大鼠心、肾组织中TNF-α蛋白表达明显减少。结论：PDTC可使心衰大鼠心、肾组织TNF-α蛋白表达减少，从而改善心衰大鼠心、肾功能。Objective： To study the impact and significance of NF-κB inhibitor pyrrolidine dithiocarbamate （PDTC） on heart failure after myocardial infarction in the rat heart and kidney TNF-α protein expression. Methods： Rat myocardial infarction heart failure model was established by ligation of anterior descending branch of the left coronary artery for 4 weeks. TNF-α protein expression of the heart and renal tissues were observed after PDTC intervention on the rats with congestive heart fail- ure by imrnunohistochemistry. Results： Compared with the sham operation PDTC intervention group, TNF-α protein expres- sioii of the heart and renal tissues was significantly reduced in the PDTC intervention group. Conclusion： PDTC could im- prove the heart and kidney function of heart failure rats by reducing the expression of TNF-α protein in the heart and kidney tissues.

关 键 词：吡咯烷二硫甲酸盐 心肌梗死 心 肾 肿瘤坏死因子-Α 

分 类 号：R969.1[医药卫生—药理学]