急性冠状动脉综合征患者血浆hs—CRP及LPA与冠状动脉狭窄程度的相关性  

Correlationship of hs-CRP, LPA in the serum and coronary artery stenosis in patients with acute coronary syndrome

作　　者：牟焕梅[1] 

机构地区：[1]山东中医药大学第二附属医院,济南250001

出　　处：《中国实用医刊》2013年第1期4-6,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨急性冠状动脉综合征患者血浆超敏c-反应蛋白（hs-CRP）、溶血磷脂酸（LPA）与冠状动脉狭窄程度的相关性。方法131例急性冠状动脉综合征患者分为ST段抬高型心肌梗死（STEMI）组41例、非ST段抬高型心肌梗死（NSTEMI）组42例、不稳型心绞痛（UAP）组48例，再选取30例健康人为对照组。所有入选者测定hs．CRP和LPA，急性冠状动脉的患者行冠状动脉造影判断狭窄的程度。结果四组间hs-CRP、LPA有明显差异，STEMI组高于NSTEMI组，NSTEMI组高于UAP组，UAP组高于对照组。冠状动脉狭窄程度评分为（96．3±11．7）分，与hs．CRP（r=0．2764，P〈0．05）、LPA（r=0．2119，P〈0．05）呈正相关。结论急性冠状动脉综合征患者血浆hs．CRP和LPA与冠状动脉的狭窄程度有明显关系。Objective To investigate the correlationship of high sensitivity C-reactive protein （hs-CRP）, lysophosphatidic acid （LPA） and coronary artery stenosis in patients with acute coronary syndrome. Methods One hundred and thirty- one patients with acute coronary syndrome were divided into ST-segment elevation myocardialinfarction（STEMI） group（ n = 41 ）, non-ST-segment elevation myocardial infarction（NSTEMI） group （ n = 42） and unstable angina（UAP） group （ n = 48 ）. Thirty heathy people were enrolled into the con- trol group. The hs-CRP and LPA were detected in all people. Coronary artery stenosis were judged in pa- tients with acute coronary syndrome. Results As hs-CRP and LPA were compared, these of STEMI were higher than these of NSTEMI, NSTEMI higher than UAP and UAP higher than the control group. The score of Gensini was 96. 3 ± 11.7, which had a positive correlation with hs-CRP（ r =0. 2764, P 〈 0. 05 ） and LPA （ r = 0. 2119, P 〈 0.05 ）. Conclusions There has a significant correlation between hs- CRP, LPA and coronary artery stenosis.

关 键 词：急性冠状动脉综合征 超敏C-反应蛋白 溶血磷脂酸 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]