不同病程Graves病患者骨代谢生化指标与骨密度变化  

Changes of bone metabolic biochemical markers and bone mineral density in patients of Graves disease with different courses

作　　者：袁园[1] 卫红艳[1] 刘萍[1] 邱明才[1] 

机构地区：[1]天津医科大学总医院内分泌科,300052

出　　处：《中华全科医师杂志》2013年第1期54-56,共3页Chinese Journal of General Practitioners

摘　　要：对144例Graves病患者按病程（≤1年，〉1年、≤5年，〉5年）分3组，测定骨代谢生化指标与骨密度，并以26名健康者作对照。不同病程组患者血钙、磷、碱性磷酸酶（ALP）及24h尿磷、镁显著高于对照组（P〈0．01或P〈0．05），血镁、25（OH）D3、1，25（OH）2D3显著低于对照组（P〈0．01或P〈0．05），随病程延长各指标变化更明显。Graves病患者骨密度显著低于对照组（P〈0．01或P〈0．05），随病程延长下降更为明显。A total of 144 patients with Graves disease were divided into 3 groups according to their disease courses（ ≤1 year, 1 year 〈 course ≤5 years, 〉5 years）. The bone metabolic biochemical markers and bone mineral density （BMD） of 144 patients with Graves disease and 26 normal controls were observed. Compared with control group, serum levels of calcium, phosphate, alkaline phosphatase and urinary levels of phosphate and magnesium in Graves disease patients were significantly increased（P 〈0. 01 or P 〈0. 05）, but serum levels of magnesium and 25 （OH） D3, 1,25 （OH） 2 D3 were significantly decreased （ P 〈 0. 01 or P 〈 0. 05 ）. BMD of all sites in patients were significantly lower than that of normal controls（P 〈0. 01 or P 〈0. 05）.

关 键 词：骨密度 生化指标 

分 类 号：R580[医药卫生—内分泌]