慢性阻塞性肺疾病患者抑郁和认知功能损害研究  

Correlation of depression and cognitive function in patients with chronic obstructive pulmonary disease

作　　者：徐传芹[1] 何远强[1] 郑玉龙[1] 周黎阳[1] 刘淑[1] 万玉峰[1] 

机构地区：[1]江苏淮安市第二人民医院呼吸内科,223002

出　　处：《中华全科医师杂志》2013年第1期59-61,共3页Chinese Journal of General Practitioners

摘　　要：以汉密尔顿抑郁量表（HAMD）〉17分和〈17分为标准，将120例慢性阻塞性肺疾病患者分为伴发抑郁组和不伴发抑郁组，根据简易精神状态法测定患者认知功能，并测定患者血氧饱和度及肺功能。120例患者中54例合并抑郁，HAMD评分与患者的血氧饱和度以及肺功能呈负相关（P〈0．05）；多因素回归分析显示，性别、血氧饱和度及精神状态总分与患者的抑郁情绪存在统计学差异（P〈0．05）；抑郁组精神状态分数较非抑郁组明显降低（P〈0．05），与血氧饱和度呈正相关（P〈0．01）；精神状态分数与HAMD评分呈负相关（r=-0．549，P〈0．01）。Based upon the measure of depression as defined by Hamilton depression scale （HAMD） scores 〉 17, 120 patients with chronic obstructive pulmonary disease （COPD） were classified into 2 groups： COPD patients with or without depression. According to the mini-mental state examination （MMSE） , the cognitive functions of all patients were evaluated. Meanwhile, oxygen saturation and pulmonary function were measured by blood gas analyzer and spirometer respectively. Fifty-four COPD patients were complicated with depression. HAMD scores were significantly negatively correlated with oxygen saturation and pulmonary function （ P 〈 0. 05 ）. Multiple regression analysis revealed that gender, oxygen saturation and MMSE scores were risk factors of depression （P 〈 0. 05）. MMSE scores decreased more obviously in the COPD patients with depression and were positively correlated with oxygen saturation （ P 〈 0. 01 ）. A negative correlation existed between MMSE scores and HAMD scores （r = - 0. 549, P 〈 0. 05）.

关 键 词：肺疾病 慢性阻塞性 抑郁 

分 类 号：R563.9[医药卫生—呼吸系统]