药学监护对2型糖尿病患者出院后用药的影响  

Effects of Pharmaceutical Care on Drug Use of Type 2 Diabetes Patients after Discharge

作　　者：李妍[1] 高玉霞[2] 刘丽亚[3] 赵霞[1] 李宏建[1] 苏乐群[1] 

机构地区：[1]山东省千佛山医院药学部,济南250014 [2]胜利石油管理局胜利医院药剂科,山东东营257000 [3]章丘市人民医院药剂科,山东章丘250200

出　　处：《中国药房》2013年第2期173-176,共4页China Pharmacy

基　　金：山东省自然科学基金资助项目(No.ZR2010HL017)

摘　　要：目的:评价规范化药学监护对于2型糖尿病患者出院后用药依从性等指标的影响。方法:设计一项随机、对照、前瞻性试验,试验组患者接受临床药师提供的全程化药学服务,对照组患者接受传统医疗服务。在患者出院1个月后随访调查,考察患者出院后的用药依从性、药品不良事件(ADE)发生率、复诊(或再入院)率和满意度等各项指标,评价患者住院期间所接受的药学服务对其出院后用药的影响。结果:与对照组比较,试验组患者对于胰岛素、促泌剂、双胍类、α-糖苷酶抑制剂的数量依从性及时间依从性,均显示有统计学差异(P<0.05),而对噻唑烷二酮类药的依从性无统计学差异(P>0.05);2组患者总的ADE发生率比较无统计学差异(P<0.05),但可预防的和严重ADE的发生率比较2组均有统计学差异(分别为P<0.05和P<0.01);复诊(或再入院)率无统计学差异(P>0.05);满意度有极显著的统计学差异(P<0.01)。结论:为2型糖尿病住院患者提供规范化的药学监护,可改善患者出院后对于多数药品的用药依从性,提高患者的满意度,降低可预防的和严重ADE的发生率,而对于患者复诊(或再入院)率无显著影响。To evaluate the effect of standard pharmaceutical care on medication compliance of type 2 diabetic patients after discharge. METHODS： In a randomized control prospective trial, trial group received whole-coursing pharmaceutical care by clinical pharmacists, while control group received traditional medical service. Through a follow-up 1 month after the patients discharged from the hospital, medication compliance, incidence of ADE, readmission （return visit） rate and patient satisfaction were investigated to evaluate the impact of pharmaceutical care on drug use of patients after discharge. RESULTS： Compared with control group, there were statistical significance in the number and time compliance of trial group when they used insulin, insulin secretagogues, biguanides and a-glycosidase inhibitors （P〈0.05）, while there was no significant difference when they used thiazolidinediones （P〉0.05）. There was no statistical significance between 2 groups for the total incidence of ADE （P〈0.05）, while there was statistical significance between 2 groups for the incidence of preventable or severe ADE（P〈0.05 or P〈0.01）. There was no statistical significance for readmission （return visit） rate between 2 groups （P〉0.05） ; the satisfaction degree of patients had dramatically statistical significance （P〈0.01）. CONCLUSION： Standardized pharmaceutical care provided for the type 2 diabetic in-patients can improve the patients＇ satisfaction and medication compliance for most drugs after discharg, and it lowers the incidence of preventable and severe ADE. However, there is no significant difference for readmission （return visit） rate.

关 键 词：2型糖尿病 药学监护 依从性 药品不良事件 

分 类 号：R952[医药卫生—药学]