CaSiO_3/TiO_2复合生物陶瓷的制备与体外性能研究  

Preparation and in vitro Properties of CaSiO_3/TiO_2 Composite Bioceramics

作　　者：虞慧娴[1] 宁聪琴[1] 

机构地区：[1]中国科学院上海硅酸盐研究所,上海200050

出　　处：《无机材料学报》2013年第1期69-73,共5页Journal of Inorganic Materials

基　　金：国家自然科学基金(50732002)~~

摘　　要：CaSiO3陶瓷作为潜在的生物材料受到广泛研究,它生物活性好,但化学稳定性、生物相容性、烧结以及力学性能不理想。本研究利用固相反应法分别将CaSiO3与TiO2以摩尔比2:1、3:1以及5:1进行混合,在1100℃下煅烧制备了物相为β-CaSiO3与CaTiSiO5的CaSiO3/TiO2复合陶瓷。复合陶瓷的化学稳定性、常压下煅烧的致密度、力学性能比CaSiO3陶瓷都得到了较大提升。随着CaSiO3含量上升,复合陶瓷力学性能及化学稳定性上升,但在模拟体液中诱导磷灰石形成的能力明显下降。研究结果表明,CaSiO3/TiO2复合陶瓷是一种有应用潜力的骨修复材料,且材料性能可通过改变组分实现调控以适应骨修复需要。CaSiO3 has attracted much attention as a bone substitute due to its strong ability to induce the formation of bonelike apatite in vitro. However, its poor chemical stability, biocompatibility, sintering and mechanical proper- ties limit its further applications. In the present study, CaSiO3/TiO2 composites with initial CaSiOa/TiO2 molar ratios at 2：1, 3：1 and 5：1 were prepared by solid-state reaction method. CaSiOa/TiO2 ceramics sintered at 1100℃ with the crystal phases of CaSiO3 and CaTiSiO5 were found to have optimistic sintering behavior, mechanical properties and degradability compared with pure CaSiO3 ceramics. With the CaSiO3 content increased, the mechanical properties were enhanced while the in vitro bioactivity and biodegradability decreased. All these results suggest that CaSiO3/TiO2 composite ceramics maybe a prospective candidate for bone repair and the properties can be adjusted by changing their chemical compositions to adapt to bone regeneration.

关 键 词：含钛硅酸盐陶瓷 CaSiO3 TIO2 磷灰石形成能力 降解性 

分 类 号：TB332[一般工业技术—材料科学与工程]