蜡球造孔法制备多孔HA陶瓷支架及其性能优化  

Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

作　　者：赵婧[1] 李金雨[2] 智伟[2] 鲁雄[2] 贾治彬[2] 翁杰[2] 

机构地区：[1]西南交通大学机械工程学院,成都610031 [2]西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,成都610031

出　　处：《无机材料学报》2013年第1期74-78,共5页Journal of Inorganic Materials

基　　金：国家重大科学研究计划(2012CB933602);国家自然科学基金(51205327;51172188);中央高校基本科研业务费专项资金(A0920502051113-95);四川省青年科技基金创新团队项目(2010JQ0081)~~

摘　　要：组织工程支架的贯通性对其体内生物学表现具有重要影响。采用甲壳素溶胶体系和蜡球造孔剂制备多孔羟基磷灰石(HA)陶瓷支架,考查在相同模压条件下,不同浆料/造孔剂比例对多孔HA陶瓷支架的孔隙率、收缩率、贯通性、多孔结构以及抗压强度的影响。结果表明:该方法可以制备具有高孔隙的多孔HA陶瓷支架,随着造孔剂比例的增大,支架的贯通性更好,当浆料/造孔剂比例为1:1.2时可以得到孔隙率、贯通性、力学性能最优的多孔HA陶瓷支架。Interconnectivity of tissue engineering scaffolds plays a very important role in biological performance in vivo. In this work, chitin sol and wax spheres were used for preparing porous hydroxyapatite （HA） ceramics scaffolds by particle leaching and gel-casting methods. Under the same mounded casting condition, the effect of ratio of slurry/wax pore former on porosity, shrinkage, interconnectivity, porous structure and compressive strength were investigated systematically. Porous HA ceramic scaffolds were evaluated by gravimetric method, stereomicroscope, X-ray diffraction （XRD）, scanning electron microscope （SEM） and universal testing machine. The results show that the present method is an effective method to fabricate a highly porous HA ceramic scaffolds. With increasing the ratio of slurry/wax spheres, the interconnectivity gets better and the optimal ratio of slurry/wax spheres is 1：1.2.

关 键 词：多孔HA陶瓷支架 蜡球堆积 贯通性 抗压强度 

分 类 号：R318[医药卫生—生物医学工程]