溶胶–凝胶生物活性玻璃的结构特征及其对糖尿病创面修复作用的研究  

Structural Properties and Wound Healing Effect of the Sol-Gel Bioactive Glass on Diabetic Skin Wounds

作　　者：林才[1,2,3] 毛葱[1,2] 李玉莉[1,2] 张娟娟[1,2] 苗国厚[1,2] 陈晓峰[1,2] 

机构地区：[1]国家人体组织功能重建工程技术研究中心,广州510006 [2]华南理工大学材料科学与工程学院,广州510640 [3]温州医学院附属第一医院烧伤科,温州325000

出　　处：《无机材料学报》2013年第1期103-108,共6页Journal of Inorganic Materials

基　　金：国家重点基础研究发展计划(973计划)(2011CB606204;2012CB619100);国家自然科学基金(50830101;51172073);华南理工大学中央高校基本科研业务费(2012ZP0001);浙江省自然科学基金重点项目(Z2080985)~~

摘　　要：采用熔融法和溶胶-凝胶法分别制备了生物活性玻璃45S5和SGBG,通过SEM、BET及XRD等方法对它们的微观结构进行了表征,并建立了SD大鼠糖尿病皮肤创面模型,通过对创面愈合时间、创面愈合率以及HE染色分析,探讨了生物活性玻璃对促进糖尿病难愈创面愈合的效果。结果表明,与凡士林组相比,生物活性玻璃组能加速创面愈合,且SGBG具有纳米结构,其比表面积更大,与45S5相比能缩短糖尿病创面的愈合时间,提高愈合速度。组织学分析表明生物活性玻璃能促进肉芽组织的生长。由此表明生物活性玻璃能促进大鼠糖尿病创面的修复,且具有纳米结构的SGBG效果更好。The 45S5 bioactive glass （45S5） was prepared by a melting process, while sol-gel bioactive glass （SGBG） was obtained by Sol-Gel method. The bioactive glasses were characterized by SEM, BET and XRD. Then the wound healing effect was investigated through the wound healing time, wound healing rate and histology examination. The results indicate that the bioactive glass can lessen the wound healing time and increase the healing rates of diabetic rats. Compared with the 45S5, SGBG can promote wound healing of diabetic rats more quickly and efficiently due to the larger surface area and nanostructure. Histological examination shows that bioactive glasses promote the proliferation of fibroblasts and growth of granulation tissue. All results suggest that bioactive glass can accelerate the recovery of skin wounds and SGBG with nanostructure has a better healing effect in diabetesimpaired models.

关 键 词：生物活性玻璃 溶胶-凝胶 创面修复 糖尿病 

分 类 号：TQ174[化学工程—陶瓷工业]