Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects  

作　　者：Dongxin Zhao Song Chen Shuguang Duo Chengang Xiang Jun Jia Mina Guo Wei Lai Shichun LU Hongkui Deng 

机构地区：[1]Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China [2]Center for Life Sciences, Peking University, Beijing 100871, China [3]Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking University, Shenzhen, Guangdong, China [4]Beijing You-An Hospital, Capital Medical University, Beijing 100069, China

出　　处：《Cell Research》2013年第1期157-161,共5页细胞研究（英文版）

摘　　要：Promoting the functional maturation of the desired cell types derived from human pluripotent stem cells （hPSCs） remains a major challenge, especially for hepatocytes, as routine access to metabolically functional hepatocytes would enable their use in drug toxicity screening. Although previous attempts to induce hepatic specification from hPSCs yielded cells possessing some hepatic features,

关 键 词：多能干细胞 细胞代谢 肝细胞 人类 成熟 多能性 缺陷 纠正 

分 类 号：Q813[生物学—生物工程] Q251